ArticleJournal of molecular neuroscience : MN2009
Clearance and phosphorylation of alpha-synuclein are inhibited in methionine sulfoxide reductase a null yeast cells.
Article in Journal of molecular neuroscience : MN, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 37 citations in OpenAlex.
- A rationally designed microbial consortium modulates neurodegeneration in a Drosophila melanogaster model of Parkinson's disease.NPJ biofilms and microbiomes · 2025Article
- Methionine sulfoxide reductase A (MsrA) mediates the ubiquitination of 14-3-3 protein isotypes in brain.Free radical biology & medicine · 2018Article
- The Functions of the Mammalian Methionine Sulfoxide Reductase System and Related Diseases.Antioxidants (Basel, Switzerland) · 2018Review
- Dimethyl sulfide protects against oxidative stress and extends lifespan via a methionine sulfoxide reductase A-dependent catalytic mechanism.Aging cell · 2017Article
- Cisplatin and Pemetrexed Activate AXL and AXL Inhibitor BGB324 Enhances Mesothelioma Cell Death from Chemotherapy.Frontiers in pharmacology · 2017Article
- Regulation of chemo-sensitivity in ovarian cancer via a stroma dependent glutathione pathway.Translational cancer research · 2016Article
- From the baker to the bedside: yeast models of Parkinson's disease.Microbial cell (Graz, Austria) · 2015Review
- Convergent signaling pathways--interaction between methionine oxidation and serine/threonine/tyrosine O-phosphorylation.Cell stress & chaperones · 2015Article
- Hyperglycemia and redox status regulate RUNX2 DNA-binding and an angiogenic phenotype in endothelial cells.Microvascular research · 2015Article
- Phosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's disease.PLoS genetics · 2014Article
- Circles within circles: crosstalk between protein Ser/Thr/Tyr-phosphorylation and Met oxidation.BMC bioinformatics · 2013Article
- Dopamine-mediated oxidation of methionine 127 in α-synuclein causes cytotoxicity and oligomerization of α-synuclein.PloS one · 2013Article
- Thiol-redox signaling, dopaminergic cell death, and Parkinson's disease.Antioxidants & redox signaling · 2012Review
- Contribution of yeast models to neurodegeneration research.Journal of biomedicine & biotechnology · 2012Review
- Induction of methionine-sulfoxide reductases protects neurons from amyloid β-protein insults in vitro and in vivo.Biochemistry · 2011Article
- Methionine oxidation of Sup35 protein induces formation of the [PSI+] prion in a yeast peroxiredoxin mutant.The Journal of biological chemistry · 2011Article
- Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease.Disease models & mechanisms · 2011Article
- Quantification of reserve pool dopamine in methionine sulfoxide reductase A null mice.Neuroscience · 2011Article
- Decreased Phosphorylation and Increased Methionine Oxidation of α-Synuclein in the Methionine Sulfoxide Reductase A Knockout Mouse.Journal of amino acids · 2011Article
- Dopamine D(2) receptor function is compromised in the brain of the methionine sulfoxide reductase A knockout mouse.Journal of neurochemistry · 2010Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Aggregated alpha-synuclein and the point mutations Ala30Pro and Ala53Thr of alpha-synuclein are associated with Parkinson's disease. The physiological roles of alpha-synuclein and methionine oxidation of the alpha-synuclein protein structure and function are not fully understood. Methionine sulfoxide reductase A (MsrA) reduces methionine sulfoxide residues and functions as an antioxidant. To monitor the effect of methionine oxidation to alpha-synuclein on basic cellular processes, alpha-synucleins were expressed in msrA null mutant and wild-type yeast cells. Protein degradation was inhibited in the alpha-synuclein-expressing msrA null mutant cells compared to alpha-synuclein-expressing wild-type cells. Increased inhibition of degradation and elevated accumulations of fibrillated proteins were observed in SynA30P-expressing msrA null mutant cells. Additionally, methionine oxidation inhibited alpha-synuclein phosphorylation in yeast cells and in vitro by casein kinase 2. Thus, a compromised MsrA function combined with alpha-synuclein overexpression may promote processes leading to synucleinopathies.
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