ArticlePloS one2009
Human guanylate binding proteins potentiate the anti-chlamydia effects of interferon-gamma.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
63 citing papers in PubMed, 102 citations in OpenAlex.
- Chlamydia trachomatis orchestrates multifaceted host cell manipulation for immune evasion.Communications biology · 2026Review
- Emerging Insights into Protein Post-Translational Modifications in Chlamydia-Host Interactions.The American journal of pathology · 2025Review
- Inflammasomes primarily restrict cytosoliceLife · 2025Article
- Interferon-gamma 1b-induced gene expression alters neutrophil function in patients with chronic granulomatous disease.PloS one · 2025Observational
- Inflammasomes primarily restrict cytosolicbioRxiv : the preprint server for biology · 2024Article
- Restriction and evasion: a review of IFNγ-mediated cell-autonomous defense pathways during genital Chlamydia infection.Pathogens and disease · 2024Review
- Article
- In vivo interferon-gamma induced changes in gene expression dramatically alter neutrophil phenotype.PloS one · 2022Article
- Human NAIP/NLRC4 and NLRP3 inflammasomes detect Salmonella type III secretion system activities to restrict intracellular bacterial replication.PLoS pathogens · 2022Article
- Human guanylate binding proteins: nanomachines orchestrating host defense.The FEBS journal · 2021Review
- Interferon-induced GTPases orchestrate host cell-autonomous defence against bacterial pathogens.Biochemical Society transactions · 2021Review
- Article
- Direct binding of polymeric GBP1 to LPS disrupts bacterial cell envelope functions.The EMBO journal · 2020Article
- Effects of Bacillus cereus PAS38 on Immune-Related Differentially Expressed Genes of Spleen in Broilers.Probiotics and antimicrobial proteins · 2020Article
- Interferon-γ Possesses Anti-Microbial and Immunomodulatory Activity on aMicroorganisms · 2020Article
- Plasma GBP2 promoter methylation is associated with advanced stages in breast cancer.Genetics and molecular biology · 2020Article
- Alternatively Activated Macrophages Are Host Cells forFrontiers in microbiology · 2019Article
- Guanylate-Binding Protein 1: An Emerging Target in Inflammation and Cancer.Frontiers in immunology · 2019Review
- Ptr/CTL0175 Is Required for the Efficient Recovery ofFrontiers in microbiology · 2019Article
- Proteome analysis reveals a role of rainbow trout lymphoid organs during Yersinia ruckeri infection process.Scientific reports · 2018Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
Abstract
Chlamydiae are obligate intracellular pathogens that are sensitive to pro-inflammatory cytokine interferon-gamma. IFN-gamma-inducible murine p47 GTPases have been demonstrated to function in resistance to chlamydia infection in vivo and in vitro. Because the human genome does not encode IFN-gamma-inducible homologues of these proteins, the significance of the p47 GTPase findings to chlamydia pathogenesis in humans is unclear. Here we report a pair of IFN-gamma-inducible proteins, the human guanylate binding proteins (hGBPs) 1 and 2 that potentiate the anti-chlamydial properties of IFN-gamma. hGBP1 and 2 localize to the inclusion membrane, and their anti-chlamydial functions required the GTPase domain. Alone, hGBP1 or 2 have mild, but statistically significant and reproducible negative effects on the growth of Chlamydia trachomatis, whilst having potent anti-chlamydial activity in conjunction with treatment with a sub-inhibitory concentration of IFN-gamma. Thus, hGBPs appear to potentiate the anti-chlamydial effects of IFN-gamma. Indeed, depletion of hGBP1 and 2 in cells treated with IFN-gamma led to an increase in inclusion size, indicative of better growth. Interestingly, chlamydia species/strains harboring the full-length version of the putative cytotoxin gene, which has been suggested to confer resistance to IFN-gamma was not affected by hGBP overexpression. These findings identify the guanylate binding proteins as potentiators of IFN-gamma inhibition of C. trachomatis growth, and may be the targets of the chlamydial cytotoxin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.