ArticlePloS one2009
Factors predicting and reducing mortality in patients with invasive Staphylococcus aureus disease in a developing country.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 50 citations in OpenAlex.
- The role of the Panton-Valentine leucocidin toxin in staphylococcal disease: a systematic review and meta-analysis.The Lancet. Infectious diseases · 2013Pooled it
- Prevalence and Characterization of Methicillin-ResistantFoods (Basel, Switzerland) · 2026Article
- Antibacterial Activity of Venom from the Puff Adder (International journal of microbiology · 2023Article
- Investigation of Virulence Genes ofThe Canadian journal of infectious diseases & medical microbiology = Journal canadien des maladies infectieuses et de la microbiologie medicale · 2021Article
- Development of a vaccine against Staphylococcus aureus invasive infections: Evidence based on human immunity, genetics and bacterial evasion mechanisms.FEMS microbiology reviews · 2020Review
- Phenotypic and Molecular Identification of Vancomycin Resistance in Clinical Staphylococcus Aureus Isolates in Osogbo, Nigeria.European journal of microbiology & immunology · 2018Article
- Is methicillin-resistantRisk management and healthcare policy · 2018Article
- Patient Characteristics, Management, and Predictors of Outcome from Severe Community-Onset Staphylococcal Sepsis in Northeast Thailand: A Prospective Multicenter Study.The American journal of tropical medicine and hygiene · 2017Observational
- Detection of Panton-valentine Leukocidin Gene Isoforms ofAdvanced biomedical research · 2017Article
- Comparison of community-onset Staphylococcus argenteus and Staphylococcus aureus sepsis in Thailand: a prospective multicentre observational study.Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases · 2016Observational
- Methicillin-susceptible Staphylococcus aureus skin infections among military conscripts undergoing basic training in Bangkok, Thailand, in 2014.BMC research notes · 2016Article
- Predictive Value of C-Reactive Protein (CRP) in Identifying Fatal Outcome and Deep Infections in Staphylococcus aureus Bacteremia.PloS one · 2016Article
- Staphylococcus aureus infections: epidemiology, pathophysiology, clinical manifestations, and management.Clinical microbiology reviews · 2015Review
- Clinical and molecular epidemiology of Staphylococcus argenteus infections in Thailand.Journal of clinical microbiology · 2015Article
- Emergency care capacity in Freetown, Sierra Leone: a service evaluation.BMC emergency medicine · 2015Article
- The clinical and molecular epidemiology of Staphylococcus aureus infections in Fiji.BMC infectious diseases · 2014Article
- Staphopains modulate Staphylococcus aureus biofilm integrity.Infection and immunity · 2013Article
- Incidence and risk factors for infection in oral cancer patients undergoing different treatments protocols.BMC oral health · 2012Article
- Predictors of mortality in Staphylococcus aureus Bacteremia.Clinical microbiology reviews · 2012Review
- Recommendations for sepsis management in resource-limited settings.Intensive care medicine · 2012Review
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
backgroundInvasive Staphylococcus aureus infection is increasingly recognised as an important cause of serious sepsis across the developing world, with mortality rates higher than those in the developed world. The factors determining mortality in developing countries have not been identified.
methodsA prospective, observational study of invasive S. aureus disease was conducted at a provincial hospital in northeast Thailand over a 1-year period. All-cause and S. aureus-attributable mortality rates were determined, and the relationship was assessed between death and patient characteristics, clinical presentations, antibiotic therapy and resistance, drainage of pus and carriage of genes encoding Panton-Valentine Leukocidin (PVL). PRINCIPAL
findingsA total of 270 patients with invasive S. aureus infection were recruited. The range of clinical manifestations was broad and comparable to that described in developed countries. All-cause and S. aureus-attributable mortality rates were 26% and 20%, respectively. Early antibiotic therapy and drainage of pus were associated with a survival advantage (both p<0.001) on univariate analysis. Patients infected by a PVL gene-positive isolate (122/248 tested, 49%) had a strong survival advantage compared with patients infected by a PVL gene-negative isolate (all-cause mortality 11% versus 39% respectively, p<0.001). Multiple logistic regression analysis using all variables significant on univariate analysis revealed that age, underlying cardiac disease and respiratory infection were risk factors for all-cause and S. aureus-attributable mortality, while one or more abscesses as the presenting clinical feature and procedures for infectious source control were associated with survival.
conclusionsDrainage of pus and timely antibiotic therapy are key to the successful management of S. aureus infection in the developing world. Defining the presence of genes encoding PVL provides no practical bedside information and draws attention away from identifying verified clinical risk factors and those interventions that save lives.
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