ArticleGenetics2009
In Saccharomyces cerevisiae, yKu and subtelomeric core X sequences repress homologous recombination near telomeres as part of the same pathway.
Article in Genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 24 citations in OpenAlex.
- Poly (ADP-ribose) polymerase in yeasts: characterization and involvement in telomere maintenance.Nucleic acids research · 2025Article
- In vivo chromatin organization on native yeast telomeric regions is independent of a cis-telomere loopback conformation.Epigenetics & chromatin · 2020Article
- Recombination at subtelomeres is regulated by physical distance, double-strand break resection and chromatin status.The EMBO journal · 2017Article
- Contrasting evolutionary genome dynamics between domesticated and wild yeasts.Nature genetics · 2017Article
- Chromosome-refolding model of mating-type switching in yeast.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Sir2 regulates stability of repetitive domains differentially in the human fungal pathogen Candida albicans.Nucleic acids research · 2016Article
- The many facets of homologous recombination at telomeres.Microbial cell (Graz, Austria) · 2015Review
- Article
- Structure and function in the budding yeast nucleus.Genetics · 2012Review
- Everything you ever wanted to know about Saccharomyces cerevisiae telomeres: beginning to end.Genetics · 2012Review
- Ku must load directly onto the chromosome end in order to mediate its telomeric functions.PLoS genetics · 2011Article
- Principles of chromosomal organization: lessons from yeast.The Journal of cell biology · 2011Review
- The association of yKu with subtelomeric core X sequences prevents recombination involving telomeric sequences.Genetics · 2009Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Unlike in meiosis where recombination near telomeres is repressed, subtelomeric regions appear to recombine with each other frequently in vegetative cells with no detrimental consequences. To test whether or not such recombination is prevented in the core of chromosomes for maintenance of genome stability, we measured allelic homologous recombination (HR) along chromosome arms and between different ectopic locations. We found that there is an increase of recombination at telomeres in wild-type cells compared with sequences at proximal subtelomeric and interstitial regions of the genome. We also screened for mutations that result in an increase in HR between a telomeric sequence and a more internal sequence, which normally exhibit very low rates of HR. YKU80 was hit most frequently in our screen, and we show that the yKu heterodimer specifically represses HR in the vicinity of telomeres. This repression of HR is not explained solely by the role of yKu in maintaining telomere length, silencing, or tethering to the nuclear periphery. Analysis of mutant strains harboring deleted core X sequences revealed a role for this subtelomeric element in preventing telomeric recombination. Furthermore, core X bestowed this protection as part of the same pathway as yKu. Our findings implicate a role for both yKu and core X in stabilizing the genome against recombination events involving telomeric sequences.
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