ArticleNeurology2009
Depression and symptoms affect quality of life in psychogenic nonepileptic seizures.
Article in Neurology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment for Psychogenic Nonepileptic Seizures: A Pilot, 12 Week, Prospective, Randomized, Placebo-controlled, Double-blind, Clinical Trial of Sertraline in the Treatment of Comorbid Psychiatric Disorders in NES
Evaluation d'un Dispositif de Suivi téléphonique Sur la Qualité de Vie Dans Les Crises Psychogènes Non Epileptiques.
Neuroimaging Biomarker for Seizures
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- Outcome measurement in functional neurological disorder: a systematic review and recommendations.Journal of neurology, neurosurgery, and psychiatry · 2020Pooled it
- Pilot pharmacologic randomized controlled trial for psychogenic nonepileptic seizures.Neurology · 2010Trial
- Diagnostic Agreement and 1-Year Outcomes in Functional Neurological Disorder Following Neuroscience-Informed Assessment, Education, and Counseling: A Retrospective Cohort Study.Brain and behavior · 2026Article
- The Patients' Long-Term Insight into Day-to-Day Functioning After Establishing the Functional Seizures Diagnosis.Brain sciences · 2025Article
- Individualized psychotherapy reveals a very high prevalence of adverse life events in functional neurological disorders.Frontiers in psychiatry · 2025Article
- Brain network entropy, depression, and quality of life in people with traumatic brain injury and seizure disorders.Epilepsia open · 2024Article
- Prospective multicenter cohort study of possible psychogenic nonepileptic seizure cases-Results at 1-year follow-up examinations.Epilepsia open · 2023Article
- A systems biology approach for discovering the cellular and molecular aspects of psychogenic non-epileptic seizure.Frontiers in psychiatry · 2023Article
- Toward a possible trauma subtype of functional neurological disorder: Impact on symptom severity and physical health.Frontiers in psychiatry · 2022Article
- Resilience linked to personality dimensions, alexithymia and affective symptoms in motor functional neurological disorders.Journal of psychosomatic research · 2018Article
- Article
- Psychogenic Non-Epileptic Seizures.Current neurology and neuroscience reports · 2017Review
- Understanding the burden of focal epilepsy as a function of seizure frequency in the United States, Europe, and Brazil.Epilepsia open · 2017Article
- Long-term video EEG monitoring for diagnosis of psychogenic nonepileptic seizures.Neuropsychiatric disease and treatment · 2014Review
- Nonepileptic behavioral disorders: diagnosis and treatment.Continuum (Minneapolis, Minn.) · 2013Review
- Differentiating between nonepileptic and epileptic seizures.Nature reviews. Neurology · 2011Review
- What is Depression in Epilepsy?Frontiers in neurology · 2011Article
- Psychogenic Nonepileptic Seizures (PNES) as a Network Disorder - Evidence From Neuroimaging of Functional (Psychogenic) Neurological Disorders.Epilepsy currentsArticle
- Impact of comorbid psychogenic non-epileptic seizures on migraine: An observational study.Journal of neurosciences in rural practiceArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn patients with active epilepsy, adverse medication effects and severity of depression are correlated with health-related quality of life, but seizure frequency is not. We sought to examine if the same pattern exists in patients with psychogenic nonepileptic seizures (PNES).
methodsWe administered seizure calendars, quality of life (QOL) scales, depression scales, and symptom checklists to 49 patients with video EEG-confirmed PNES. Data analysis consisted of performing Pearson correlation coefficients, scatter plots, and t tests.
resultsDepression and symptom scores significantly increased as health-related QOL scores decreased (partial correlation coefficient r = -0.73 for both comparisons), whereas seizure count was nonsignificant (partial correlation coefficient r = -0.19).
conclusionsAs is seen in epilepsy, patients with psychogenic nonepileptic seizures demonstrate that higher depressive symptoms and somatic symptoms are independently related to worsening quality of life (QOL); however, seizure frequency is not. Seizure frequency is an important focus in patient care and treatment trials. The findings underscore the importance of, along with seizure counts, also examining QOL, depression, and somatic symptoms in patients with seizures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.