ArticleHypertension (Dallas, Tex. : 1979)2009
Genetic analysis of blood pressure in 8 mouse intercross populations.
Article in Hypertension (Dallas, Tex. : 1979), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 34 citations in OpenAlex.
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- Multi-spectral Fluorescent Reporter Influenza A Viruses Allow forbioRxiv : the preprint server for biology · 2023Article
- Genetics of murine type 2 diabetes and comorbidities.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- The Latest in Animal Models of Pulmonary Hypertension and Right Ventricular Failure.Circulation research · 2022Review
- Effects of garden cress, fenugreek and black seed on the pharmacodynamics of metoprolol: an herb-drug interaction study in rats with hypertension.Pharmaceutical biology · 2021Article
- DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress.Cell death and differentiation · 2018Article
- Advances in the Genetics of Hypertension: The Effect of Rare Variants.International journal of molecular sciences · 2018Review
- β-composite Interval Mapping for robust QTL analysis.PloS one · 2018Article
- Deletion of Nedd4-2 results in progressive kidney disease in mice.Cell death and differentiation · 2017Article
- Toll-like Receptor 4 Deficiency Reduces Oxidative Stress and Macrophage Mediated Inflammation in Hypertensive Kidney.Scientific reports · 2017Article
- Tail-Cuff Technique and Its Influence on Central Blood Pressure in the Mouse.Journal of the American Heart Association · 2017Article
- Strain survey and genetic analysis of vasoreactivity in mouse aorta.Physiological genomics · 2016Article
- Background differences in baseline and stimulated MMP levels influence abdominal aortic aneurysm susceptibility.Atherosclerosis · 2015Article
- IBI* series winner. Students as collaborators in systems biology research.Science (New York, N.Y.) · 2013Article
- Therapeutic effect of MG132 on the aortic oxidative damage and inflammatory response in OVE26 type 1 diabetic mice.Oxidative medicine and cellular longevity · 2013Article
- Identification of hypertension susceptibility loci on rat chromosome 12.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Genetic analysis of albuminuria in collaborative cross and multiple mouse intercross populations.American journal of physiology. Renal physiology · 2012Article
- Genome-wide association mapping of quantitative traits in outbred mice.G3 (Bethesda, Md.) · 2012Article
- Genetic modifiers of cardiovascular phenotype caused by elastin haploinsufficiency act by extrinsic noncomplementation.The Journal of biological chemistry · 2011Article
Corrections and comments
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
Abstract
The genetic basis of hypertension is well established, yet very few genes that cause common forms of hypertension are known. Quantitative trait locus (QTL) analyses in rodent models can guide the search for human hypertension genes, but the excellent genetic resources for mice have been underused in this regard. To address this issue, we surveyed blood pressure variation in mice from 37 inbred strains and generated 2577 mice in 8 intercross populations to perform QTL analyses of blood pressure. We identified 14 blood pressure QTL in these populations, including > or =7 regions of the mouse genome not linked previously to blood pressure. Many QTL were detected in multiple crosses, either within our study or in studies published previously, which facilitates the use of bioinformatics methods to narrow the QTL and focus the search for candidate genes. The regions of the human genome that correspond to all but 1 of the 14 blood pressure QTL in mice are linked to blood pressure in humans, suggesting that these regions contain causal genes with a conserved role in blood pressure control. These results greatly expand our knowledge of the genomic regions underlying blood pressure regulation in mice and support future studies to identify the causal genes within these QTL intervals.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.