ArticleAntimicrobial agents and chemotherapy2009
The electricidal effect is active in an experimental model of Staphylococcus epidermidis chronic foreign body osteomyelitis.
Article in Antimicrobial agents and chemotherapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Enhanced antibacterial activities of zirconia nanoparticles modified with yttrium oxide and alumina.Scientific reports · 2026Article
- Electrolytic cleaning as a biofilm control strategy on medical implants: mechanisms, evidence and translational perspectives.Frontiers in microbiology · 2026Review
- Adjunctive intraoperative pulsed direct current with cefazolin: a rabbit proof-of-concept model for prevention of prosthetic joint infection.Frontiers in cellular and infection microbiology · 2026Article
- Biofilm and the effect of sonication in a chronic Staphylococcus epidermidis orthopedic in vivo implant infection model.Journal of orthopaedic surgery and research · 2024Article
- Electric Current Application on Dental Implant Biofilms: Review.Journal of functional biomaterials · 2024Review
- Comparisons of the killing effect of direct current partially mediated by reactive oxygen species onJournal of dental sciences · 2022Article
- Effect of Low Amperage Electric Current on Staphylococcus Aureus-Strategy for Combating Bacterial Biofilms Formation on Dental Implants in Cystic Fibrosis Patients, In Vitro Study.Materials (Basel, Switzerland) · 2021Article
- Review
- Microampere Electric Current Causes Bacterial Membrane Damage and Two-Way Leakage in a Short Period of Time.Applied and environmental microbiology · 2020Article
- Electrochemical methods to enhance osseointegrated prostheses.Biomedical engineering letters · 2020Review
- Reduction ofInternational journal of environmental research and public health · 2019Article
- Effect of Direct Electrical Current on Bones Infected withJBMR plus · 2019Article
- Understanding Biofilms and Novel Approaches to the Diagnosis, Prevention, and Treatment of Medical Device-Associated Infections.Infectious disease clinics of North America · 2018Review
- Survival of Staphylococcus epidermidis in Fibroblasts and Osteoblasts.Infection and immunity · 2018Article
- Chronic tonsillitis and biofilms: a brief overview of treatment modalities.Journal of inflammation research · 2018Review
- Activity of Electrical Current in Experimental Propionibacterium acnes Foreign-Body Osteomyelitis.Antimicrobial agents and chemotherapy · 2017Article
- Pathogenic Mechanisms and Host Interactions inFrontiers in microbiology · 2017Review
- CORR Insights(®): Cathodic Voltage-controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model.Clinical orthopaedics and related research · 2016Article
- Cathodic Voltage-controlled Electrical Stimulation Plus Prolonged Vancomycin Reduce Bacterial Burden of a Titanium Implant-associated Infection in a Rodent Model.Clinical orthopaedics and related research · 2016Article
- Bacterial adhesion on biomedical surfaces covered by yttria stabilized zirconia.Journal of materials science. Materials in medicine · 2016Article
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Authors and funding
7 authors.
Funding
Abstract
Treatment with low-amperage (200 microA) electrical current was compared to intravenous doxycycline treatment or no treatment in a rabbit model of Staphylococcus epidermidis chronic foreign body osteomyelitis to determine if the electricidal effect is active in vivo. A stainless steel implant and 10(4) CFU of planktonic S. epidermidis were placed into the medullary cavity of the tibia. Four weeks later, rabbits were assigned to one of three groups with treatment administered for 21 days. The groups included those receiving no treatment (n = 10), intravenous doxycycline (n = 14; 8 mg/kg of body weight three times per day), and electrical current (n = 15; 200 microA continuous delivery). Following treatment, rabbits were sacrificed and the tibias quantitatively cultured. Bacterial load was significantly reduced in the doxycycline (median, 2.55 [range, 0.50 to 6.13] log10 CFU/g of bone) and electrical-current (median, 1.09 [range, 0.50 to 2.99] log10 CFU/g of bone) groups, compared to the level for the control group (median, 4.16 [range, 3.70 to 5.66] log10 CFU/g of bone) (P < 0.0001). Moreover, treatment with electrical current was statistically significantly more efficacious (P = 0.035) than doxycycline treatment. The electricidal effect (the bactericidal activity of low-amperage electrical current against bacterial biofilms) is active in vivo in the treatment of experimental S. epidermidis chronic foreign body osteomyelitis.
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