ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2009
Noeud vital for breathing in the brainstem: gasping--yes, eupnoea--doubtful.
Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- An inspiration-off attractor supports the robust and flexible control of breathing.Science advances · 2026Article
- Electroencephalographic assessment of pneumatic penetrating captive-bolt stunning of donkeysAnimal welfare (South Mimms, England) · 2026Article
- An inspiration-off attractor supports the robust and flexible control of breathing.bioRxiv : the preprint server for biology · 2025Article
- The intractable problems with brain death and possible solutions.Philosophy, ethics, and humanities in medicine : PEHM · 2021Review
- Antidotal effects of methylene blue against cyanide neurological toxicity: in vivo and in vitro studies.Annals of the New York Academy of Sciences · 2020Article
- A spatially dynamic network underlies the generation of inspiratory behaviors.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Use of a Non-Penetrating Captive Bolt for the Euthanasia of Neonate Piglets.Animals : an open access journal from MDPI · 2018Article
- The Use of a Mechanical Non-Penetrating Captive Bolt Device for the Euthanasia of Neonate Lambs.Animals : an open access journal from MDPI · 2018Article
- Testing the hypothesis of neurodegeneracy in respiratory network function with a priori transected arterially perfused brain stem preparation of rat.Journal of neurophysiology · 2016Article
- Perinatal hyperoxic exposure reconfigures the central respiratory network contributing to intolerance to anoxia in newborn rat pups.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Stimulation of the midbrain periaqueductal gray modulates preinspiratory neurons in the ventrolateral medulla in the rat in vivo.The Journal of comparative neurology · 2013Article
- Brainstem respiratory networks: building blocks and microcircuits.Trends in neurosciences · 2013Review
- Computational models and emergent properties of respiratory neural networks.Comprehensive Physiology · 2012Review
- The human pre-Bötzinger complex identified.Brain : a journal of neurology · 2011Article
- Mylohyoid discharge of the in situ rat: a probe of pontile respiratory activities in eupnea and gasping.Journal of applied physiology (Bethesda, Md. : 1985) · 2010Article
- Brainstem: neural networks vital for life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
For the past 200 years, various regions of the brainstem have been proposed as a 'noeud vital' for breathing-a critical region which, when destroyed, results in an irreversible cessation of breathing and death. Complicating this search for a noeud vital is the extensive network of neurons that comprises the brainstem respiratory control system of pons and medulla. Does a cessation of breathing following ablation of any region reflect the removal of a critical set of neurons whose activity generates the respiratory rhythm or does it reflect the interruption of one component of the neuronal circuit, such that this circuit cannot function, at least temporarily? An additional complication is that in contemporary neuroscience, a number of in vitro preparations have been introduced for the study of the generation of the respiratory rhythms. However, how are the rhythms that these preparations generate related to normal breathing? Are these rhythms similar to those of gasping, which is recruited when normal, eupnoeic breathing fails, or are these rhythms unique to the in vitro preparation and not related to any breathing pattern in vivo?
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