ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2009
Alterations in cholinergic sensitivity of respiratory neurons induced by pre-natal nicotine: a mechanism for respiratory dysfunction in neonatal mice.
Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 27 citations in OpenAlex.
- Cigarette smoking, nicotine dependence and anxiety disorders: a systematic review of population-based, epidemiological studies.BMC medicine · 2012Pooled it
- Prenatal smoking and drinking are associated with altered newborn autonomic functions.Pediatric research · 2023Article
- Perinatal Nicotine Reduces Chemosensitivity of Medullary 5-HT Neurons after Maturation in Culture.Neuroscience · 2020Article
- Dual recombinase fate mapping reveals a transient cholinergic phenotype in multiple populations of developing glutamatergic neurons.The Journal of comparative neurology · 2020Article
- Article
- The Difference a Decade Makes: Smoking Cessation Counseling and Screening at Pediatric Visits.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2016Article
- Developmental nicotine exposure alters cholinergic control of respiratory frequency in neonatal rats.Developmental neurobiology · 2016Article
- Cholinergic control of ventral surface chemoreceptors involves Gq/inositol 1,4,5-trisphosphate-mediated inhibition of KCNQ channels.The Journal of physiology · 2016Article
- The Alteration of Neonatal Raphe Neurons by Prenatal-Perinatal Nicotine. Meaning for Sudden Infant Death Syndrome.American journal of respiratory cell and molecular biology · 2015Article
- Impairment of Central Chemoreception in Neonatal Rats Induced by Maternal Cigarette Smoke Exposure during Pregnancy.PloS one · 2015Article
- Prenatal nicotine exposure enhances Cx43 and Panx1 unopposed channel activity in brain cells of adult offspring mice fed a high-fat/cholesterol diet.Frontiers in cellular neuroscience · 2014Article
- The cellular building blocks of breathing.Comprehensive Physiology · 2012Review
- Isolated in vitro brainstem-spinal cord preparations remain important tools in respiratory neurobiology.Respiratory physiology & neurobiology · 2012Review
- Tonic neuromodulation of the inspiratory rhythm generator.Frontiers in physiology · 2012Article
- Endogenous inhibition of the trigeminally evoked neurotransmission to cardiac vagal neurons by muscarinic acetylcholine receptors.Journal of neurophysiology · 2010Article
- Brainstem: neural networks vital for life.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2009Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Nicotine may link cigarette smoking during pregnancy with sudden infant death syndrome (SIDS). Pre-natal nicotine leads to diminished ventilatory responses to hypercarbia and reduced central chemoreception in mice at post-natal days 0-3. We studied how pre-natal nicotine exposure changes the cholinergic contribution to central respiratory chemoreception in neonatal isolated brainstem-spinal cord and slice preparations. Osmotic minipumps, implanted subcutaneously into 5-7 days pregnant mice, delivered saline or nicotine ditartrate 60 mg kg(-1) d(-1) for up to 28 days. In control preparations, acidification of the superfusion medium from pH 7.4 to 7.3 increased the frequency and reduced the amplitude of fictive respiration. In nicotine-exposed neonatal mice, the reduction in amplitude induced by acidification was reduced. In control preparations, atropine suppressed respiratory responses to acidification, while hexamethonium did not. By contrast, in nicotine-exposed preparations, hexamethonium blocked chemosensory responses but atropine did not. Our results indicate that pre-natal nicotine exposure switches cholinergic mechanisms of central chemosensory responses from muscarinic receptors to nicotinic receptors. Modification of the cholinergic contribution to central chemoreception may produce respiratory dysfunctions, as suggested by receptor-binding studies in victims of SIDS.
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