ArticleIEEE transactions on bio-medical engineering2009
Analysis of intracerebral EEG recordings of epileptic spikes: insights from a neural network model.
Article in IEEE transactions on bio-medical engineering, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 65 citations in OpenAlex.
- Regional excitability, not epileptic pathology, drives stimulation-evoked interictal spike increases.medRxiv : the preprint server for health sciences · 2026Article
- Identifying and investigating emergent behaviour in neural systems.Frontiers in neuroscience · 2026Article
- Relative contributions of different neural sources to the EEG.NeuroImage · 2023Article
- Cell to network computational model of the epileptic human hippocampus suggests specific roles of network and channel dysfunctions in the ictal and interictal oscillations.Journal of computational neuroscience · 2022Article
- Negative effects of interictal spikes on theta rhythm in human temporal lobe epilepsy.Epilepsy & behavior : E&B · 2018Article
- Sample Entropy Analysis of Noisy Atrial Electrograms during Atrial Fibrillation.Computational and mathematical methods in medicine · 2018Article
- Model-guided control of hippocampal discharges by local direct current stimulation.Scientific reports · 2017Article
- Future of seizure prediction and intervention: closing the loop.Journal of clinical neurophysiology : official publication of the American Electroencephalographic Society · 2015Review
- Computational modeling of seizure dynamics using coupled neuronal networks: factors shaping epileptiform activity.PLoS computational biology · 2015Article
- Genesis of interictal spikes in the CA1: a computational investigation.Frontiers in neural circuits · 2014Article
- Altered FMRI connectivity dynamics in temporal lobe epilepsy might explain seizure semiology.Frontiers in neurology · 2014Article
- Transient impact of spike on theta rhythm in temporal lobe epilepsy.Experimental neurology · 2013Article
- Astrocyte- neuron interaction as a mechanism responsible for generation of neural synchrony: a study based on modeling and experiments.Journal of computational neuroscience · 2013Article
- Neuron to astrocyte communication via cannabinoid receptors is necessary for sustained epileptiform activity in rat hippocampus.PloS one · 2012Article
- Bistable, irregular firing and population oscillations in a modular attractor memory network.PLoS computational biology · 2010Article
- Abnormal Excitability of Oblique Dendrites Implicated in Early Alzheimer's: A Computational Study.Frontiers in neural circuits · 2010Article
- Time-domain features of epileptic spikes as potential bio-markers of the epileptogenesis process.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2010Article
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The pathophysiological interpretation of EEG signals recorded with depth electrodes [i.e., local field potentials (LFPs)] during interictal (between seizures) or ictal (during seizures) periods is fundamental in the presurgical evaluation of patients with drug-resistant epilepsy. Our objective was to explain specific shape features of interictal spikes in the hippocampus (observed in LFPs) in terms of cell- and network-related parameters of neuronal circuits that generate these events. We developed a neural network model based on "minimal" but biologically relevant neuron models interconnected through GABAergic and glutamatergic synapses that reproduce the main physiological features of the CA1 subfield. Simulated LFPs were obtained by solving the forward problem (dipole theory) from networks including a large number ( approximately 3000) of cells. Insertion of appropriate parameters allowed the model to simulate events that closely resemble actual epileptic spikes. Moreover, the shape of the early fast component ("spike'') and the late slow component ("negative wave'') was linked to the relative contribution of glutamatergic and GABAergic synaptic currents in pyramidal cells. In addition, the model provides insights about the sensitivity of electrode localization with respect to recorded tissue volume and about the relationship between the LFP and the intracellular activity of principal cells and interneurons represented in the network.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.