ArticleJournal of the American Society for Mass Spectrometry2009
Charge-separation reactions of doubly-protonated peptides: effect of peptide chain length.
Article in Journal of the American Society for Mass Spectrometry, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Accurate Prediction of y Ions in Beam-Type Collision-Induced Dissociation Using Deep Learning.Analytical chemistry · 2022Article
- Gas-Phase Stability of Negatively Charged Organophosphate Metabolites Produced by Electrospray Ionization and Matrix-Assisted Laser Desorption/Ionization.Journal of the American Society for Mass Spectrometry · 2017Article
- N-terminal peptide sequence repetition influences the kinetics of backbone fragmentation: a manifestation of the Jahn-Teller effect?Journal of the American Society for Mass Spectrometry · 2013Article
- Carbonyl charge solvation patterns may relate to fragmentation classes in collision-activated dissociation.Journal of the American Society for Mass Spectrometry · 2012Article
- Formation of y + 10 and y + 11 ions in the collision-induced dissociation of peptide ions.Journal of the American Society for Mass Spectrometry · 2012Article
- Effect of the identity of Xaa on the fragmentation modes of doubly-protonated Ala-Ala-Xaa-Ala-Ala-Ala-Arg.Journal of the American Society for Mass Spectrometry · 2011Article
- Effect of N-terminal glutamic acid and glutamine on fragmentation of peptide ions.Journal of the American Society for Mass Spectrometry · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The collision induced dissociation of doubly-protonated (Ala)(x)His (x = 5, 6, 7, 8, 10) peptides have been studied. The major fragmentation reactions observed are symmetrical amide bond cleavages to give the complementary b(m) and y(N-m) ions, where N is the total number of residues in the peptide. Minor asymmetric cleavage to give doubly-protonated y ions also is observed, involving cleavage near the N-terminus. The shorter peptides (x = 5, 6, 7) show major cleavage of the second amide bond to yield b2 and y(N-2) ions, while (Ala)10His shows major symmetrical cleavage at the fourth and fifth amide bonds. (Ala)8His appears to be a transitional peptide in showing substantial symmetrical cleavage at the second, fourth, and fifth amide bonds. The results are in general agreement with the bifurcating nature of charge separation noted by Zubarev (J. Am. Soc. Mass Spectrom.2008, 19, 1755-1763) from a statistical analysis of a large body of doubly-protonated tryptic peptide CID mass spectra. It is shown that the b2 ion derived from doubly-protonated (Ala)5His has a protonated oxazolone structure.
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Registered trials
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