ReviewCurrent opinion in immunology2009
Genetics of hypogammaglobulinemia: what do we really know?
Review in Current opinion in immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- A Novel BLNK Gene Mutation in a Four-Year-Old Child Who Presented with Late Onset of Severe Infections and High IgM Levels and Diagnosed and Followed as X-Linked Agammaglobulinemia for Two Years.Case reports in immunology · 2022Article
- A New Missense Mutation in CD79B Leads to Autosomal Recessive Agammaglobulinemia in Two Siblings.Journal of clinical immunology · 2021Article
- An essential role for the ZnNature immunology · 2019Article
- Gastrointestinal Manifestations in X-linked Agammaglobulinemia.Journal of clinical immunology · 2017Article
- Respiratory Health and Related Quality of Life in Patients with Congenital Agammaglobulinemia in the Northern Region of the UK.Journal of clinical immunology · 2016Article
- Application of Flow Cytometry in the Evaluation of Primary Immunodeficiencies.Indian journal of pediatrics · 2016Review
- Common Variable Immunodeficiency and Circulating TFH.Journal of immunology research · 2016Article
- Mutations in Bruton's tyrosine kinase impair IgA responses.International journal of hematology · 2015Article
- ICON: the early diagnosis of congenital immunodeficiencies.Journal of clinical immunology · 2014Review
- Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population.Genes and immunity · 2012Article
- Monocyte activation is a feature of common variable immunodeficiency irrespective of plasma lipopolysaccharide levels.Clinical and experimental immunology · 2012Article
- Parental consanguinity is associated with a severe phenotype in common variable immunodeficiency.Journal of clinical immunology · 2012Article
- Toll-like receptor 4-, 7-, and 8-activated myeloid cells from patients with X-linked agammaglobulinemia produce enhanced inflammatory cytokines.The Journal of allergy and clinical immunology · 2012Article
- TNFRSF13B/TACI alterations in Greek patients with antibody deficiencies.Journal of clinical immunology · 2011Article
- Primary B-cell deficiencies reveal a link between human IL-17-producing CD4 T-cell homeostasis and B-cell differentiation.PloS one · 2011Article
- TLR signaling and effector functions are intact in XLA neutrophils.Clinical immunology (Orlando, Fla.) · 2010Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
In the past, immunodeficiencies were categorized based on clinical and laboratory findings in the affected patient. Now we are more likely to define them based on the specific gene involved. One might expect this shift to increase the precision and clarity of diagnosis but in the last few years it has become increasingly clear that identification of a mutation in a specific gene may not tell the whole story. Some gene defects may reliably result in clinical disease, others may act as susceptibility factors that are more common in patients with immunodeficiency but can also be found in otherwise healthy individuals. Distinguishing between these two types of gene defects is essential for informative genetic counseling.
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