Trial reportAntiviral research1990
A study of the efficacy of the bradykinin antagonist, NPC 567, in rhinovirus infections in human volunteers.
Trial report in Antiviral research, 1990. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 40 citations in OpenAlex.
- A study of the action of bradykinin and bradykinin analogues in the human nasal airway.The Journal of physiology · 1994Trial
- Utility of animal and in vivo experimental infection of humans with rhinoviruses in the development of therapeutic agents for viral exacerbations of asthma and chronic obstructive pulmonary disease.Pulmonary pharmacology & therapeutics · 2015Review
- Nasal cytokines as mediators of illness during the common cold.Current allergy and asthma reports · 2005Review
- Viral rhinitis.Current allergy and asthma reports · 2001Review
- Association of rhinovirus infections with asthma.Clinical microbiology reviews · 1999Review
- The kinin system in rhinitis and asthma.Clinical reviews in allergy & immunology · 1998Review
- Epidemiology, pathogenesis, and treatment of the common cold.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 1997Review
- Problems and prospects of developing effective therapy for common cold viruses.Trends in microbiology · 1997Review
- Cromolyns: treatment for the common cold.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 1996Review
- The common cold: current therapy and natural history.The Journal of allergy and clinical immunology · 1995Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In a double-blind placebo controlled trial intranasal NPC 567, a bradykinin antagonist, failed to alleviate the symptoms of experimental rhinovirus colds. Indeed, there was evidence that the drug enhanced the symptoms although no irritant effect was detected on the uninfected nasal mucosa.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.