Evidence map›Paper›PMID 19650670›Full record

ReviewMolecular diagnosis & therapy2009

Molecular and contextual markers of hepatitis C virus and drug abuse.

Paul Shapshak, Charurut Somboonwit, Lydia N Drumright, Simon D W Frost, Deborah Commins, Timothy L Tellinghuisen, William K Scott, Robert Duncan, Clyde McCoy, J Bryan Page and 9 more

Open access · bronzeAbstract readReview
In one paragraph

Review in Molecular diagnosis & therapy, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Patterns of Infectious Disease Associated With Injection Drug Use in Massachusetts.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023
    Article
  2. Estimated prevalence of Hepatitis C Virus infection in Canada, 2011.Canada communicable disease report = Releve des maladies transmissibles au Canada · 2014
    Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 3 countries.

Paul ShapshakDivision of Infectious Disease and International Medicine, Department of Internal Medicine, Tampa General Hospital, University of South Florida, College of Medicine, Tampa, Florida, USA. pshapshak@gmail.com
Charurut Somboonwit
Lydia N Drumright
Simon D W Frost
Deborah Commins
Timothy L Tellinghuisen
William K Scott
Robert Duncan
Clyde McCoy
J Bryan Page
Brian Giunta
Francisco Fernandez
Elyse Singer
Andrew Levine
Alireza Minagar
Oluwadayo Oluwadara
Taiwo Kotila
Francesco Chiappelli
John T Sinnott
University of Miami · USUniversity of South Florida · USUniversity of California, Los Angeles · USFlorida College · USLouisiana State University Health Sciences Center Shreveport · USScripps Research Institute · USUniversity of California, San Diego · USUniversity of Cambridge · GBUniversity of Ibadan · NGUniversity of Southern California · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
NATIONAL NEUROLOGICAL AIDS BANKU24MH100929 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2013 to 2023
$12.5M
National Neurological AIDS Bank (NNAB)R24NS038841 · NINDS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 1998 to 2007
$12.0M
National Neurological AIDS BankU01MH083500 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SINGER, ELYSE J · 2008 to 2012
$7.2M
COMMUNITY DEPOSIT AND REVIEW OF BIOCHEMICAL DATABASESR01GM056529 · NIGMS · WASHINGTON UNIVERSITY · PI KAZIC, TONI · 1997 to 2006
$2.4M
CLINICAL AND FUNDAMENTAL IMMUNOLOGYT32AI007126 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SAXON, ANDREW · 1985 to 2006
$1.5M
HIV INFECTION POTENTIAL /IDU-RELATED INJECTION MATERIALSR01DA012580 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI PAGE, JOHN BRYAN · 2000 to 2002
$1.2M
GENE EXPRESSION IN HIV ASSOCIATED DEMENTIA BRAINR21DA014533 · NIDA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI SHAPSHAK, PAUL · 2001 to 2004
$795k
COCAINE, BLOOD-BRAIN BARRIER AND DISEASE PROGRESSIONR01DA010442 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FIALA, MILAN · 1996 to 1998
–
DRUGS OF ABUSE: EFFECTS ON CD4 LYMPHOCYTESR29DA007683 · NIDA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CHIAPPELLI, FRANCESCO · 1992 to 1996
–
NCI NIH HHS CA16042NCI NIH HHS P30 CA016042NIAID NIH HHS AI07126NIAID NIH HHS T32 AI007126NIDA NIH HHS DA07683NIDA NIH HHS DA10442NIDA NIH HHS DA12580NIDA NIH HHS DA14533NIDA NIH HHS R01 DA012580NIDA NIH HHS R21 DA014533NIGMS NIH HHS GM056529NIGMS NIH HHS R01 GM056529NIMH NIH HHS U01 MH083500NIMH NIH HHS U24 MH100929NINDS NIH HHS NS038841NINDS NIH HHS R24 NS038841
6 · The paper itself

Abstract

The spread of hepatitis C virus (HCV) infection involves a complex interplay of social risks, and molecular factors of both virus and host. Injection drug abuse is the most powerful risk factor for HCV infection, followed by sexual transmission and additional non-injection drug abuse factors such as co-infection with other viruses and barriers to treatment. It is clearly important to understand the wider context in which the factors related to HCV infection occur. This understanding is required for a comprehensive approach leading to the successful prevention, diagnosis, and treatment of HCV. An additional consideration is that current treatments and advanced molecular methods are generally unavailable to socially disadvantaged patients. Thus, the recognition of behavioral/social, viral, and host factors as components of an integrated approach to HCV is important to help this vulnerable group. Equally important, this approach is key to the development of personalized patient treatment - a significant goal in global healthcare. In this review, we discuss recent findings concerning the impact of drug abuse, epidemiology, social behavior, virology, immunopathology, and genetics on HCV infection and the course of disease.

Indexed as

AnimalsBiomarkersHepacivirusHepatitis CHumansSubstance-Related DisordersBiomarkers

Identifiers

PMID19650670
PMCPMC4447498
OpenAlexW2014693074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.