ArticleDevelopmental dynamics : an official publication of the American Association of Anatomists2009
Emx3 is required for the differentiation of dorsal telencephalic neurons.
Article in Developmental dynamics : an official publication of the American Association of Anatomists, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
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- Hallmarks of primary neurulation are conserved in the zebrafish forebrain.Communications biology · 2021Article
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- Homeogene emx1 is required for nephron distal segment development in zebrafish.Scientific reports · 2018Article
- Identification of a neuronal population in the telencephalon essential for fear conditioning in zebrafish.BMC biology · 2018Article
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- Opposing Shh and Fgf signals initiate nasotemporal patterning of the zebrafish retina.Development (Cambridge, England) · 2015Article
- Reevaluating Emx gene phylogeny: homopolymeric amino acid tracts as a potential factor obscuring orthology signals in cyclostome genes.BMC evolutionary biology · 2015Article
- Genes and signaling networks regulated during zebrafish optic vesicle morphogenesis.BMC genomics · 2014Article
- Localization of BDNF expression in the developing brain of zebrafish.Journal of anatomy · 2014Article
- Subdivisions of the adult zebrafish pallium based on molecular marker analysis.F1000Research · 2014Article
- Fgf16 is required for specification of GABAergic neurons and oligodendrocytes in the zebrafish forebrain.PloS one · 2014Article
- TigarB causes mitochondrial dysfunction and neuronal loss in PINK1 deficiency.Annals of neurology · 2013Article
- Precocious acquisition of neuroepithelial character in the eye field underlies the onset of eye morphogenesis.Developmental cell · 2013Article
- Eph/Ephrin signalling maintains eye field segregation from adjacent neural plate territories during forebrain morphogenesis.Development (Cambridge, England) · 2013Article
- Robo2--slit and Dcc--netrin1 coordinate neuron axonal pathfinding within the embryonic axon tracts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
emx3 is first expressed in prospective telencephalic cells at the anterior border of the zebrafish neural plate. Knockdown of Emx3 function by morpholino reduces the expression of markers specific to dorsal telencephalon, and impairs axon tract formation. Rescue of both early and late markers requires low-level expression of emx3 at the one- or two-somite stage. Higher emx3 expression levels cause dorsal telencephalic markers to expand ventrally, which points to a possible role of emx3 in specifying dorsal telencephalon and a potential new function for Wnt/beta-catenin pathway activation. In contrast to mice, where Emx2 plays a major role in dorsal telencephalic development, knockdown of zebrafish Emx2 apparently does not affect telencephalic development. Similarly, Emx1 knockdown has little effect. Previously, emx3 was thought to be fish-specific. However, we found all three emx orthologs in Xenopus tropicalis and opossum (Monodelphis domestica) genomes, indicating that emx3 was present in an ancestral tetrapod genome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.