ArticleMammalian genome : official journal of the International Mammalian Genome Society2009
Mouse, man, and meaning: bridging the semantics of mouse phenotype and human disease.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Commentary on Shimoyama et al. (2012): three ontologies to define phenotype measurement data.Frontiers in genetics · 2014Article
- Editorial: biological ontologies and semantic biology.Frontiers in genetics · 2014Article
- Construction and accessibility of a cross-species phenotype ontology along with gene annotations for biomedical research.F1000Research · 2013Article
- Semantically enabling a genome-wide association study database.Journal of biomedical semantics · 2012Article
- Ontology-based cross-species integration and analysis of Saccharomyces cerevisiae phenotypes.Journal of biomedical semantics · 2012Article
- Exact score distribution computation for ontological similarity searches.BMC bioinformatics · 2011Article
- Improving ontologies by automatic reasoning and evaluation of logical definitions.BMC bioinformatics · 2011Article
- Genotype-Phenotype Map Characteristics of an In silico Heart Cell.Frontiers in physiology · 2011Article
- A gene-phenotype network for the laboratory mouse and its implications for systematic phenotyping.PloS one · 2011Article
- The RIKEN integrated database of mammals.Nucleic acids research · 2011Article
- Pathbase and the MPATH ontology. Community resources for mouse histopathology.Veterinary pathology · 2010Article
- A framework for comparing phenotype annotations of orthologous genes.Studies in health technology and informatics · 2010Article
- EuroPhenome: a repository for high-throughput mouse phenotyping data.Nucleic acids research · 2010Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Now that the laboratory mouse genome is sequenced and the annotation of its gene content is improving, the next major challenge is the annotation of the phenotypic associations of mouse genes. This requires the development of systematic phenotyping pipelines that use standardized phenotyping procedures which allow comparison across laboratories. It also requires the development of a sophisticated informatics infrastructure for the description and interchange of phenotype data. Here we focus on the current state of the art in the description of data produced by systematic phenotyping approaches using ontologies, in particular, the EQ (Entity-Quality) approach, and what developments are required to facilitate the linking of phenotypic descriptions of mutant mice to human diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.