ArticleFolia microbiologica2009
Identification of Anaplasma phagocytophilum and Borrelia burgdorferi sensu lato in patients with erythema migrans.
Article in Folia microbiologica, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Human granulocytotropic anaplasmosis-A systematic review and analysis of the literature.PLoS neglected tropical diseases · 2024Pooled it
- A systematic review on the impact of gestational Lyme disease in humans on the fetus and newborn.PloS one · 2018Pooled it
- Advanced Molecular and Microscopic Diagnostics Suggest CongenitalMicroorganisms · 2026Article
- Perinatal transmission ofFrontiers in medicine · 2026Review
- Global prevalence ofNew microbes and new infections · 2025Article
- Culture and other direct detection methods to diagnose human granulocytic anaplasmosis.American journal of clinical pathology · 2025Article
- Global prevalence ofBMJ open · 2024Article
- Article
- Case presentation and management of Lyme disease patients: a 9-year retrospective analysis in France.Frontiers in medicine · 2023Article
- Human Co-Infections betweenPathogens (Basel, Switzerland) · 2022Review
- Unexpected failure ofCurrent research in parasitology & vector-borne diseases · 2021Article
- Evaluation of Disease Causality of RarePathogens (Basel, Switzerland) · 2020Review
- A review on the eco-epidemiology and clinical management of human granulocytic anaplasmosis and its agent in Europe.Parasites & vectors · 2019Review
- Lyme disease risk in southern California: abiotic and environmental drivers of Ixodes pacificus (Acari: Ixodidae) density and infection prevalence with Borrelia burgdorferi.Parasites & vectors · 2017Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Anaplasma phagocytophilum has been first isolated from the blood of two Czech patients simultaneously with a cultivation of Borrelia burgdorferi sensu lato from their erythema migrans lesions. Cultivation of different Borrelia spp. from 12 erythema migrans biopsies, from 2 blood, one liquor and one placenta sample in BSK-H medium was successful. Adapted conventional methods targeting 16S rRNA and OspA genes for real-time polymerase chain reaction (PCR) and partial sequencing of these genes together with microscopical examinations of the blood smears provided a direct detection of the B. afzelii, B. burgdorferi, B. garinii, B. valaisiana and B. bissettii in the skin, B. garinii in the blood, placenta and liquor in 24 (36.3 %) patients, and A. phagocytophilum in 10 (15 %) patients with erythema migrans. Positive indirect IgM immunofluorescence against Anaplasma sp. was obtained in 7 cases, specific IgG antibodies were detected in 12 patients. Three women suffering from erythema migrans in the first trimester had positive PCR for Anaplasma and/or for Borrelia in the blood and two of them, later, in the placenta. Interpretation of laboratory data can bring important contribution to establishing the role of Anaplasma sp. in erythema migrans and forming the principle of precaution with laboratory diagnosis during pregnancy which always should be reflected in the resistance of Anaplasma sp. toward penicillins.
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