ReviewGenetica2010
Gene therapy vectors: the prospects and potentials of the cut-and-paste transposons.
Review in Genetica, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed.
- A Preliminary Evaluation ofPharmaceutics · 2026Article
- Development of an inducible stable producer cell line for rAAV production.Biochemical engineering journal · 2026Article
- Sublethal concentrations of antibiotics enhance transmission of antibiotic resistance genes in environmentalFrontiers in microbiology · 2025Article
- Cell factory engineering: Challenges and opportunities for synthetic biology applications.Biotechnology and bioengineering · 2023Review
- Transposon-encoded nucleases use guide RNAs to selfishly bias their inheritance.bioRxiv : the preprint server for biology · 2023Article
- Review
- Frequent Transposition of Multiple Insertion Sequences inFrontiers in microbiology · 2021Article
- Review
- PiggyBac transposon-based polyadenylation-signal trap for genome-wide mutagenesis in mice.Scientific reports · 2016Article
- PiggyBac transposon vectors: the tools of the human gene encoding.Translational lung cancer research · 2016Review
- Mechanisms of DNA Transposition.Microbiology spectrum · 2015Review
- The road to HIV-1 integrase inhibitors: the case for supporting basic research.Future virology · 2014Article
- Biomaterial strategies for stem cell maintenance during in vitro expansion.Tissue engineering. Part B, Reviews · 2014Review
- Crosstalk between transposase subunits during cleavage of the mariner transposon.Nucleic acids research · 2014Article
- Knockout of an outer membrane protein operon of Anaplasma marginale by transposon mutagenesis.BMC genomics · 2014Article
- Target capture during Mos1 transposition.The Journal of biological chemistry · 2014Article
- Article
- A resurrected mammalian hAT transposable element and a closely related insect element are highly active in human cell culture.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Hsmar1 transposition is sensitive to the topology of the transposon donor and the target.PloS one · 2013Article
- Remnant living cells that escape cell loss in late-stage tumors exhibit cancer stem cell-like characteristics.Cell death & disease · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Gene therapy applications require efficient tools for the stable delivery of genetic information into eukaryotic genomes. Most current gene delivery strategies are based on viral vectors. However, a number of drawbacks, such as the limited cargo capacity, host immune response and mutational risks, highlight the need for alternative gene delivery tools. A comprehensive gene therapy tool kit should contain a range of vectors and techniques that can be adapted to different targets and purposes. Transposons provide a potentially powerful approach. However, transposons encompass a large number of different molecular mechanisms, some of which are better suited to gene delivery applications than others. Here, we consider the range and potentials of the various mechanisms, focusing on the cut-and-paste transposons as one of the more promising avenues towards gene therapy applications. Several cut-and-paste transposition systems are currently under development. We will first consider the mechanisms of piggyBac and the hAT family elements Tol1 and Tol2, before focusing on the mariner family elements including Mos1, Himar1 and Hsmar1.
Indexed as
Identifiers
19649713What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.