ArticleJournal of cancer research and clinical oncology2010
Systems biology approach to identification of biomarkers for metastatic progression in gastric cancer.
Article in Journal of cancer research and clinical oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Cancer-associated fibroblast-derived fibulin-5 promotes epithelial-mesenchymal transition in diffuse-type gastric cancer via cAMP response element-binding protein pathway, showing poor prognosis.Experimental & molecular medicine · 2025Article
- Integrated network toxicology, machine learning algorithms and TMT proteomics reveal the mechanism of 18β glycyrrhetinic acid against gastric cancer.Frontiers in genetics · 2025Article
- NEDD4 and NEDD4L: Ubiquitin Ligases Closely Related to Digestive Diseases.Biomolecules · 2024Review
- Emerging roles of the HECT E3 ubiquitin ligases in gastric cancer.Pathology oncology research : POR · 2023Review
- Identification and functional characterization of long non-coding RNAs in human gastric cancer.Oncology letters · 2018Article
- Copy number variation of E3 ubiquitin ligase genes in peripheral blood leukocyte and colorectal cancer.Scientific reports · 2016Article
- Clinical significance of ECT2 expression in tissue and serum of gastric cancer patients.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2016Article
- Targeting the ubiquitin pathway for cancer treatment.Biochimica et biophysica acta · 2015Review
- Identification of differentially-expressed genes in intestinal gastric cancer by microarray analysis.Genomics, proteomics & bioinformatics · 2014Article
- miR-152 suppresses gastric cancer cell proliferation and motility by targeting CD151.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2014Article
- Up-regulation of ECT2 is associated with poor prognosis in gastric cancer patients.International journal of clinical and experimental pathology · 2014Article
- NEDD4: a promising target for cancer therapy.Current cancer drug targets · 2014Review
- Article
- Upregulated INHBA expression is associated with poor survival in gastric cancer.Medical oncology (Northwood, London, England) · 2012Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeGastric cancer is usually diagnosed at later stages (stages III and IV) in China, and the overall 5-year survival rate is low at 40%. Metastases are responsible for the majority of cancer fatalities. The molecular mechanisms governing metastasis are poorly understood.
methodsWe have analyzed gene expression data based on gene interaction networks and molecular pathways rather than separate genes utilizing hierarchical cluster analysis, Gene ontology analysis and pathway analysis.
resultsWe have analyzed gene expression data from advanced gastric cancer tissues, corresponding adjacent noncancerous gastric tissues and its peritonium metastasis. Our studies indicated that metastatic tumor was related to changes in apoptosis pathway and proteasome degradation pathway, TRAF2 and IRF3 are up-regulated in apoptosis pathway, NEDD4 and UBE1 are up-regulated in proteasome degradation pathway.
conclusionThe advent of high-throughput investigation of gene using Microarray technology, a systems approach relying on groups of interacting genes is essential for understanding the processes of cancer. We have identified apoptosis pathway and proteasome degradation pathway associated with metastasis.
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