Trial reportEuropean journal of applied physiology2009
Cytokine and hormone responses to resistance training.
Trial report in European journal of applied physiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed, 1 synthesis or guideline pooled it, 167 citations in OpenAlex.
- The Impact of Exercise Training on the Brain and Cognition in Type 2 Diabetes, and its Physiological Mediators: A Systematic Review.Sports medicine - open · 2025Pooled it
- Acute Hormonal and Inflammatory Responses following Lower and Upper Body Resistance Exercises Performed to Volitional Failure.International journal of molecular sciences · 2024Trial
- Acute Effects of High-Intensity Functional Training and Moderate-Intensity Continuous Training on Cognitive Functions in Young Adults.International journal of environmental research and public health · 2022Trial
- Aqua cycling for immunological recovery after intensive, eccentric exercise.European journal of applied physiology · 2019Trial
- Enhanced Coupling Within Gonadotropic and Adrenocorticotropic Axes by Moderate Exercise in Healthy Men.The Journal of clinical endocrinology and metabolism · 2017Trial
- Effects of resistance training at different loads on inflammatory markers in young adults.European journal of applied physiology · 2017Trial
- Hormonal and neuromuscular responses to mechanical vibration applied to upper extremity muscles.PloS one · 2014Trial
- Hormone responses to a continuous bout of rock climbing in men.European journal of applied physiology · 2011Trial
- Exercise increases interleukin-10 levels both intraarticularly and peri-synovially in patients with knee osteoarthritis: a randomized controlled trial.Arthritis research & therapy · 2010Trial
- Acute Biochemical Responses to Competitive Tournament Load in Female Handball Players: Hormonal, Inflammatory and Muscle Damage Markers.Life (Basel, Switzerland) · 2026Article
- The acute impact of resistance exercise training on cardiovascular parameters in trained and untrained adults with high blood pressure.European journal of applied physiology · 2025Article
- Impact of different concurrent training sequencing schemes on overnight systemic immunological regulation in adolescent athletes.Frontiers in physiology · 2025Article
- Supplementation Strategies for Strength and Power Athletes: Carbohydrate, Protein, and Amino Acid Ingestion.Nutrients · 2024Review
- Effect of a resistance exercise at acute moderate altitude on muscle health biomarkers.Pflugers Archiv : European journal of physiology · 2024Article
- Comparison of the cytokine responses to acute strength exercise between oral contraceptive users and naturally cycling women.European journal of applied physiology · 2024Article
- Endocrine responses of the stress system to different types of exercise.Reviews in endocrine & metabolic disorders · 2023Review
- Is There a Role for Exercise When Treating Patients with Cancer with Immune Checkpoint Inhibitors? A Scoping Review.Cancers · 2022Article
- Acute neuromuscular and hormonal responses to 20 versus 40% velocity loss in males and females before and after 8 weeks of velocity-loss resistance training.Experimental physiology · 2022Article
- Resistance exercise with different workloads have distinct effects on cellular respiration of peripheral blood mononuclear cells.Physiological reports · 2022Article
- Myokine Response to Blood-Flow Restricted Resistance Exercise in Younger and Older Males in an Untrained and Resistance-Trained State: A Pilot Study.Journal of science in sport and exercise · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study examined the effects of heavy resistance training on physiological acute exercise-induced fatigue (5 x 10 RM leg press) changes after two loading protocols with the same relative intensity (%) (5 x 10 RM(Rel)) and the same absolute load (kg) (5 x 10 RM(Abs)) as in pretraining in men (n = 12). Exercise-induced neuromuscular (maximal strength and muscle power output), acute cytokine and hormonal adaptations (i.e., total and free testosterone, cortisol, growth hormone (GH), insulin-like growth factor-1 (IGF-1), IGF binding protein-3 (IGFBP-3), interleukin-1 receptor antagonist (IL-1ra), IL-1beta, IL-6, and IL-10 and metabolic responses (i.e., blood lactate) were measured before and after exercise. The resistance training induced similar acute responses in serum cortisol concentration but increased responses in anabolic hormones of FT and GH, as well as inflammation-responsive cytokine IL-6 and the anti-inflammatory cytokine IL-10, when the same relative load was used. This response was balanced by a higher release of pro-inflammatory cytokines IL-1beta and cytokine inhibitors (IL-1ra) when both the same relative and absolute load was used after training. This enhanced hormonal and cytokine response to strength exercise at a given relative exercise intensity after strength training occurred with greater accumulated fatigue and metabolic demand (i.e., blood lactate accumulation). The magnitude of metabolic demand or the fatigue experienced during the resistance exercise session influences the hormonal and cytokine response patterns. Similar relative intensities may elicit not only higher exercise-induced fatigue but also an increased acute hormonal and cytokine response during the initial phase of a resistance training period.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.