ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2009
Heavy silicone oil (Densiron-68) for the treatment of persistent macular holes: Densiron-68 endotamponade for persistent macular holes.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 71 citations in OpenAlex.
- Optimal approaches for managing recurrent macular holes: a comprehensive systematic review and meta-analysis.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Pooled it
- FIRST FAILED MACULAR HOLE SURGERY OR REOPENING OF A PREVIOUSLY CLOSED HOLE: Do We Gain by Reoperating?-A Systematic Review and Meta-analysis.Retina (Philadelphia, Pa.) · 2020Pooled it
- The use of amniotic membrane or inverted internal limiting membrane flap for large or refractory macular holes: a prospective, comparative study using microperimetry.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Trial
- Long-term outcomes of Oxane Hd as intraocular tamponade in the treatment of complicated retinal detachment.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2010Trial
- Refractory macular hole surgery with amniotic membrane transplant functional assessment.International journal of retina and vitreous · 2025Article
- [Macular hole: Differential diagnosis, treatment options and new guideline recommendations].Die Ophthalmologie · 2024Review
- Autologous internal limiting membrane transplantation achieves anatomic closure and functional improvement in the treatment of large, persistent macular holes.International journal of retina and vitreous · 2024Article
- Closure rates and patterns after light silicone oil tamponade for persistent full-thickness macular holes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2023Article
- Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy.BMC ophthalmology · 2022Article
- Refractory full thickness macular hole: current surgical management.Eye (London, England) · 2022Review
- Biocompatibility of intraocular liquid tamponade agents: an update.Eye (London, England) · 2021Review
- Persistent macular holes - what is the best strategy for revision?Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2021Article
- Human amniotic membrane for the treatment of large and refractory macular holes: a retrospective, multicentric, interventional study.International journal of retina and vitreous · 2021Article
- Autologous full-thickness retinal transplant for refractory large macular holes.International journal of retina and vitreous · 2020Article
- Surgical technique for approaching chronic or persistent macular holes: Two case reports.American journal of ophthalmology case reports · 2020Article
- Literature Review of Surgical Treatment in Idiopathic Full-Thickness Macular Hole.Clinical ophthalmology (Auckland, N.Z.) · 2020Review
- Optimal management of idiopathic macular holes.Clinical ophthalmology (Auckland, N.Z.) · 2016Review
- A review of current management of vitreomacular traction and macular hole.Journal of ophthalmology · 2015Review
- Vitreous substitutes: the present and the future.BioMed research international · 2014Review
- Management of Stage IV Macular Holes: When Standard Surgery Fails.Case reports in ophthalmology · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the efficacy and safety of the use of Densiron-68 as intraocular endotamponade for the treatment of persisting macular holes (persistent MHs).
methodsRetrospective interventional case study on 23 consecutive eyes showing persistent MHs after unsuccessful primary surgery that underwent retreatment with pars plana vitrectomy and Densiron-68 filling. The main outcome measures were: anatomic closure evaluated with optical coherence tomography (OCT), final best-corrected visual acuity (BCVA), and postoperative complications.
resultsA total of 23 patients (52-88 years) were studied. Pre-operative OCT showed full-thickness MH (mean size 560 microm) in all patients. Densiron-68 was left in situ for 1.5-3 months. Final follow-up time was 12 months after the last surgery. Postoperative OCT showed the complete closure of the PMH in 20 of 23 eyes. Pre-operative BCVA ranged from 20/200 to 20/630 (1.50-1.00 logMAR, mean 1.14). Final postoperative BCVA ranged from 20/30 to 20/400 (0.18-1.30 logMAR, mean. 0.61). Nineteen eyes (82%) showed a significant increase in visual acuity by at least three lines: 11 (47%) patients gained at least four lines. Three eyes remained unchanged (13%). One case deteriorated by two lines (4%). No major complications were recorded.
conclusionsRetreatment with Densiron-68 filling was safe and achieved encouraging anatomic and functional results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.