ArticleVascular health and risk management2009
Abdominal obesity is associated with microalbuminuria and an elevated cardiovascular risk profile in patients with hypertension.
Article in Vascular health and risk management, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38 citing papers in PubMed, 98 citations in OpenAlex.
- A Systematic Review and Meta-Analysis of the Association Between Obesity and Albuminuria in Asian People.International journal of hypertension · 2026Review
- Association between relative fat mass (RFM) and chronic kidney disease (CKD): data from NHANES 2005-2018.Scientific reports · 2025Article
- Longitudinal Trajectories of Albuminuria and eGFR in Type 2 Diabetes Mellitus: Natural Progression of Diabetic Kidney Disease.Journal of diabetes research · 2025Observational
- High miR-126-3p levels associated with cardiovascular events in a general population.European journal of internal medicine · 2023Article
- Body roundness index is related to the low estimated glomerular filtration rate in Chinese population: A cross-sectional study.Frontiers in endocrinology · 2023Article
- Lycopene Improves Metabolic Disorders and Liver Injury Induced by a Hight-Fat Diet in Obese Rats.Molecules (Basel, Switzerland) · 2022Article
- Waist-hip ratio measured by bioelectrical impedance analysis as a valuable predictor of chronic kidney disease development.BMC nephrology · 2022Article
- The Beneficial Effects of Bariatric-Surgery-Induced Weight Loss on Renal Function.Metabolites · 2022Review
- Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study.EClinicalMedicine · 2022Article
- Obesity, Weight Loss, Lifestyle Interventions, and Autosomal Dominant Polycystic Kidney Disease.Kidney and dialysis · 2022Article
- Development of a Risk Model for Predicting Microalbuminuria in the Chinese Population Using Machine Learning Algorithms.Frontiers in medicine · 2022Article
- Impact of Obesity in Kidney Diseases.Nutrients · 2021Review
- Anti-obesity potential ofSaudi journal of biological sciences · 2020Article
- Use of SGLT-2 Inhibitors in Patients with Type 2 Diabetes Mellitus and Abdominal Obesity: An Asian Perspective and Expert Recommendations.Diabetes & metabolism journal · 2020Review
- Obesity and kidney disease: hidden consequences of the epidemic.Future science OA · 2017Review
- Obesity and Kidney Disease: Hidden Consequences of the Epidemic.Kidney diseases (Basel, Switzerland) · 2017Article
- Obesity and kidney disease: hidden consequences of the epidemic.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2017Review
- Obesity and kidney disease: hidden consequences of the epidemic.Pediatric nephrology (Berlin, Germany) · 2017Article
- Obesity and kidney disease: hidden consequences of the epidemic.Journal of nephrology · 2017Review
- Obesity and kidney disease: hidden consequences of the epidemic.Clinical kidney journal · 2017Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundOverweight and obesity are frequently associated with preventable death and have emerged as a major challenge to public health. There is an ongoing debate on the role of abdominal obesity and its value in predicting cardiovascular and renal outcomes. The present analysis evaluates the prevalence of microalbuminuria (MAU) and conventional cardiovascular risk factors in relation to measures of general and abdominal obesity.
methodsIn this multinational, observational study, 20828 hypertensive out-patients from 26 countries including Europe, North and Latin America, Middle East, and Asia were analyzed. Urinary dipstick screening for MAU was performed as well as data on patient demographics, anthropometric measures, cardiovascular risk factors, comorbid conditions, and cardiovascular drug therapy collected. MAU prevalence was determined by a stepwise logistic regression analysis with cardiovascular risk factors as univariate.
resultsIn the univariate analysis, MAU prevalence systematically increased with body mass index (BMI) from 54.4% (1st tertial) to 62.1% (3rd tertial) (p < 0.0001), an increase which was also observed for waist circumference (WC). At any level of BMI, MAU increased with WC from 53.5%, 54.8%, and 55.0% (1st tertial of WC in all three BMI tertials) to 61.4%, 62.1%, and 64.0% (3rd tertial of WC in all BMI tertials) (p < 0.0001). In the multivariate analysis, WC, but not BMI was independently associated with MAU. Furthermore, overweight/obesity were associated with the presence of modifiable and nonmodifiable risk factors.
conclusionAn abnormal WC, but not BMI appears to be independently associated with MAU, an early marker of cardiovascular and renal risk. Increasing WC confers an incremental risk for MAU at any level of BMI, underlining the prognostic importance of abdominal fat accumulation beyond general obesity.
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