ArticlePloS one2009
Evolution and phylogenetic analysis of full-length VP3 genes of Eastern Mediterranean bluetongue virus isolates.
Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 37 citations in OpenAlex.
- Bluetongue virus: current perspectives on characterisation and the need to formalise nomenclature in an era of rapidly evolving technology.The Journal of general virology · 2026Review
- Bluetongue in China: Current Status of Viruses, Vectors, Detection Methods, and Vaccines.Transboundary and emerging diseases · 2026Review
- A novel narnavirus is widespread in Saccharomyces cerevisiae and impacts multiple host phenotypes.G3 (Bethesda, Md.) · 2023Article
- Defining virus-carrier networks that shape the composition of the mosquito core virome of a local ecosystem.Virus evolution · 2022Article
- Global emergence and evolutionary dynamics of bluetongue virus.Scientific reports · 2020Article
- Complete Genome Sequence of a Bluetongue Virus Serotype 15 Strain Isolated from China in 1996.Genome announcements · 2018Article
- Epidemiological characteristics and clinicopathological features of bluetongue in sheep and cattle, during the 2014 BTV serotype 4 incursion in Greece.Tropical animal health and production · 2016Article
- Article
- FLDS: A Comprehensive dsRNA Sequencing Method for Intracellular RNA Virus Surveillance.Microbes and environments · 2016Article
- Turnover Rate of NS3 Proteins Modulates Bluetongue Virus Replication Kinetics in a Host-Specific Manner.Journal of virology · 2015Article
- Full-Genome Sequencing as a Basis for Molecular Epidemiology Studies of Bluetongue Virus in India.PloS one · 2015Article
- Full genome characterization of the culicoides-borne marsupial orbiviruses: Wallal virus, Mudjinbarry virus and Warrego viruses.PloS one · 2014Article
- Full-Genome Sequence of Bluetongue Virus Serotype 1 (BTV-1) Strain Y863, the First BTV-1 Isolate of Eastern Origin Found in China.Genome announcements · 2013Article
- Full genome sequencing of Corriparta virus, identifies California mosquito pool virus as a member of the Corriparta virus species.PloS one · 2013Article
- Genome sequence of a reassortant strain of bluetongue virus serotype 23 from western India.Journal of virology · 2012Article
- The genome sequence of a reassortant bluetongue virus serotype 3 from India.Journal of virology · 2012Article
- The genome sequence of bluetongue virus type 10 from India: evidence for circulation of a western topotype vaccine strain.Journal of virology · 2012Article
- Liao ning virus in China.Virology journal · 2011Article
- Complete genome characterisation of a novel 26th bluetongue virus serotype from Kuwait.PloS one · 2011Article
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Bluetongue virus (BTV) is the 'type' species of the genus Orbivirus within the family Reoviridae. The BTV genome is composed of ten linear segments of double-stranded RNA (dsRNA), each of which codes for one of ten distinct viral proteins. Previous phylogenetic comparisons have evaluated variations in genome segment 3 (Seg-3) nucleotide sequence as way to identify the geographical origin (different topotypes) of BTV isolates. The full-length nucleotide sequence of genome Seg-3 was determined for thirty BTV isolates recovered in the eastern Mediterranean region, the Balkans and other geographic areas (Spain, India, Malaysia and Africa). These data were compared, based on molecular variability, positive-selection-analysis and maximum-likelihood phylogenetic reconstructions (using appropriate substitution models) to 24 previously published sequences, revealing their evolutionary relationships. These analyses indicate that negative selection is a major force in the evolution of BTV, restricting nucleotide variability, reducing the evolutionary rate of Seg-3 and potentially of other regions of the BTV genome. Phylogenetic analysis of the BTV-4 strains isolated over a relatively long time interval (1979-2000), in a single geographic area (Greece), showed a low level of nucleotide diversity, indicating that the virus can circulate almost unchanged for many years. These analyses also show that the recent incursions into south-eastern Europe were caused by BTV strains belonging to two different major-lineages: representing an 'eastern' (BTV-9, -16 and -1) and a 'western' (BTV-4) group/topotype. Epidemiological and phylogenetic analyses indicate that these viruses originated from a geographic area to the east and southeast of Greece (including Cyprus and the Middle East), which appears to represent an important ecological niche for the virus that is likely to represent a continuing source of future BTV incursions into Europe.
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