Evidence map›Paper›PMID 19649242›Full record

ArticlePloS one2009

HIV prevalence and associated risk factors among individuals aged 13-34 years in Rural Western Kenya.

Pauli N Amornkul, Hilde Vandenhoudt, Peter Nasokho, Frank Odhiambo, Dufton Mwaengo, Allen Hightower, Anne Buvé, Ambrose Misore, John Vulule, Charles Vitek and 4 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in PloS one, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06446752 (A Phase 3 Randomized, Observer-Blind, Placebo-Controlled Study to Assess Efficacy of Meningococcal Group B), which is not on this map. Cited by 85 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
85citing papers in PubMed, 2 pooled it
22.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06446752 phase3active not recruitingnot on this mapstarted 2024, after this paper: background citation

A Phase 3 Randomized, Observer-Blind, Placebo-Controlled Study to Assess Efficacy of Meningococcal Group B (rMenB+OMV NZ (Bexsero)) in Preventing Gonococcal Infection Among South African Cis-Gender Women

TypeinterventionalSponsorUniversity of WashingtonRan2024 to 2027Enrolled1,100ConditionsGonorrhea, Gonorrhea of Pharynx, Gonorrhea of Anus, Gonorrhea of CervixArmsBexsero, Placebo
3 · Its place in the literature

Who cites it

85 citing papers in PubMed, 2 syntheses or guidelines pooled it, 150 citations in OpenAlex.

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25 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 5 countries.

Pauli N AmornkulDivision of HIV/AIDS Prevention, US Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America. pamornkul@iavi.org
Hilde Vandenhoudt
Peter Nasokho
Frank Odhiambo
Dufton Mwaengo
Allen Hightower
Anne Buvé
Ambrose Misore
John Vulule
Charles Vitek
Judith Glynn
Alan Greenberg
Laurence Slutsker
Kevin M De Cock
Centers for Disease Control and Prevention · USKenya Medical Research Institute · KECenters for Disease Control and Prevention · UGInstituut voor Tropische Geneeskunde · BELondon School of Hygiene & Tropical Medicine · GBMinistry of Health · KE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesTo estimate HIV prevalence and characterize risk factors among young adults in Asembo, rural western Kenya.

designCommunity-based cross-sectional survey.

methodsFrom a demographic surveillance system, we selected a random sample of residents aged 13-34 years, who were contacted at home and invited to a nearby mobile study site. Consent procedures for non-emancipated minors required assent and parental consent. From October 2003 - April 2004, consenting participants were interviewed on risk behavior and tested for HIV and HSV-2. HIV voluntary counseling and testing was offered.

resultsOf 2606 eligible residents, 1822 (70%) enrolled. Primary reasons for refusal included not wanting blood taken, not wanting to learn HIV status, and partner/parental objection. Females comprised 53% of 1762 participants providing blood. Adjusted HIV prevalence was 15.4% overall: 20.5% among females and 10.2% among males. HIV prevalence was highest in women aged 25-29 years (36.5%) and men aged 30-34 years (41.1%). HSV-2 prevalence was 40.0% overall: 53% among females, 25.8% among males. In multivariate models stratified by gender and marital status, HIV infection was strongly associated with age, higher number of sex partners, widowhood, and HSV-2 seropositivity.

conclusionsAsembo has extremely high HIV and HSV-2 prevalence, and probable high incidence, among young adults. Further research on circumstances around HIV acquisition in young women and novel prevention strategies (vaccines, microbicides, pre-exposure prophylaxis, HSV-2 prevention, etc.) are urgently needed.

Indexed as

HIV SeroprevalenceRural PopulationAdolescentAdultAIDS SerodiagnosisFemaleHumansKenyaMaleMultivariate AnalysisPopulation SurveillanceRisk FactorsSexual PartnersYoung Adult

Identifiers

PMID19649242
PMCPMC2714463
OpenAlexW2152179057

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.