Evidence map›Paper›PMID 19648949›Full record

ReviewNature reviews. Microbiology2009

Listeria monocytogenes - from saprophyte to intracellular pathogen.

Nancy E Freitag, Gary C Port, Maurine D Miner

Abstract readReview
In one paragraph

Review in Nature reviews. Microbiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 287 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
287citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

287 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Internalization ofAnnals of medicine · 2026
    Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Avoidance of MAIT cells is an essential determinant ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  9. Host methylglyoxal activates theProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The roles of theJournal of bacteriology · 2026
    Article
  15. Article
  16. Article
  17. Premature stop codons inBioscience of microbiota, food and health · 2026
    Article
  18. Article
  19. Listeria monocytogenes: from a saprophytic to a cytosolic virulent pathogen.World journal of microbiology & biotechnology · 2025
    Review
  20. Article

227 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Nancy E FreitagDepartment of Microbiology and Immunology (MC790), University of Illinois at Chicago, 835 South Wolcott Avenue, Chicago, Illinois 606127344, USA. nfreitag@uic.edu
Gary C Port
Maurine D Miner

Funding

Listeria Virulence Gene Expression Within Host CellsR01AI041816 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FREITAG, NANCY ELIZABETH · 2001 to 2010
$3.9M
INTERDISCIPLINARY PROGRAM IN BACTERIAL PATHOGENESIST32AI055396 · NIAID · UNIVERSITY OF WASHINGTON · PI FANG, FERRIC C · 2003 to 2019
$2.8M
Listeria virulence gene expression within host cellsR56AI041816 · NIAID · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FREITAG, NANCY ELIZABETH · 2012 to 2012
$399k
LISTERIA VIRULENCE GENE EXPRESSION WITHIN HOST CELLSR29AI041816 · NIAID · WAYNE STATE UNIVERSITY · PI FREITAG, NANCY · 1997 to 2001
$253k
NIAID NIH HHS AI41816NIAID NIH HHS AI55396NIAID NIH HHS R01 AI041816NIAID NIH HHS R29 AI041816NIAID NIH HHS R56 AI041816NIAID NIH HHS T32 AI055396
6 · The paper itself

Abstract

Listeria monocytogenes is a bacterium that lives in the soil as a saprophyte but is capable of making the transition into a pathogen following its ingestion by susceptible humans or animals. Recent studies suggest that L. monocytogenes mediates its saprophyte-to-cytosolic-parasite transition through the careful modulation of the activity of a virulence regulatory protein known as PrfA, using a range of environmental cues that include available carbon sources. In this Progress article we describe the regulation of PrfA and its role in the L. monocytogenes transition from the saprophytic stage to the virulent intracellular stage.

Indexed as

Gene Expression Regulation, BacterialAnimalsBacterial ProteinsHumansListeria monocytogenesListeriosisModels, BiologicalModels, MolecularProtein Structure, QuaternarySoil MicrobiologyVirulenceVirulence FactorsBacterial ProteinsVirulence Factors

Identifiers

PMID19648949
PMCPMC2813567

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.