ArticleNature structural & molecular biology2009
Drosophila MSL complex globally acetylates H4K16 on the male X chromosome for dosage compensation.
Article in Nature structural & molecular biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 87 papers.
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Who cites it
87 citing papers in PubMed.
- Prospero prevents lineage-specific loss and gain by regulating cyclin E and mitosis during Drosophila neurogenesis.EMBO reports · 2026Article
- Transcription initiation drives dosage compensation establishment and maintenance in maleScience advances · 2026Article
- Nucleotide-Resolution Mapping Reveals Specific MLE Binding Site on roX2 lncRNA.Journal of molecular biology · 2026Article
- Hangover regulates gene expression by limiting NSL-mediated H4K16 acetylation.Nucleic acids research · 2025Article
- X-chromosome upregulation operates on a gene-by-gene basis at RNA and protein levels.Nature communications · 2025Article
- Mammalian H4K16ac regulates the spatiotemporal order of genome replication rather than gene expression.Nucleic acids research · 2025Article
- Chromatin dynamics of a large-sized genome provides insights into polyphenism and X0 dosage compensation of locusts.Nature genetics · 2025Article
- Chromatin Landscape Is Associated With Sex-Biased Expression and Drosophila-Like Dosage Compensation of the Z Chromosome in Artemia franciscana.Molecular biology and evolution · 2025Article
- Sex Chromosome Dosage Compensation in Insects.Insects · 2025Review
- Development and evolution of Drosophila chromatin landscape in a 3D genome context.Nature communications · 2024Article
- Single-cell RNA-seq of Drosophila miranda testis reveals the evolution and trajectory of germline sex chromosome regulation.PLoS biology · 2024Article
- Dosage Compensation inInternational journal of molecular sciences · 2022Review
- Induction and inhibition of Drosophila X chromosome gene expression are both impeded by the dosage compensation complex.G3 (Bethesda, Md.) · 2022Article
- Genomic and functional conservation of lncRNAs: lessons from flies.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- The Chromatin Accessibility Landscape of Nonalcoholic Fatty Liver Disease Progression.Molecules and cells · 2022Article
- Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function.Molecular cell · 2022Review
- An explainable artificial intelligence approach for decoding the enhancer histone modifications code and identification of novel enhancers in Drosophila.Genome biology · 2021Article
- Mechanistically comparing reproductive manipulations caused by selfish chromosomes and bacterial symbionts.Heredity · 2021Review
- Analysis of cell-type-specific chromatin modifications and gene expression in Drosophila neurons that direct reproductive behavior.PLoS genetics · 2021Article
- Epigenetic Changes During Human Thyroid Cell Differentiation.Thyroid : official journal of the American Thyroid Association · 2020Article
27 more citing papers are in PubMed but not listed here.
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5 authors.
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Abstract
The Drosophila melanogaster male-specific lethal (MSL) complex binds the single male X chromosome to upregulate gene expression to equal that from the two female X chromosomes. However, it has been puzzling that approximately 25% of transcribed genes on the X chromosome do not stably recruit MSL complex. Here we find that almost all active genes on the X chromosome are associated with robust H4 Lys16 acetylation (H4K16ac), the histone modification catalyzed by the MSL complex. The distribution of H4K16ac is much broader than that of the MSL complex, and our results favor the idea that chromosome-wide H4K16ac reflects transient association of the MSL complex, occurring through spreading or chromosomal looping. Our results parallel those of localized Polycomb repressive complex and its more broadly distributed chromatin mark, trimethylated histone H3 Lys27 (H3K27me3), suggesting a common principle for the establishment of active and silenced chromatin domains.
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