ArticleMayo Clinic proceedings2009
Disease associations with monoclonal gammopathy of undetermined significance: a population-based study of 17,398 patients.
Article in Mayo Clinic proceedings, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 88 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
88 citing papers in PubMed, 3 syntheses or guidelines pooled it, 199 citations in OpenAlex.
- Brazilian Academy of Neurology recommendations for diagnosis, management, and treatment of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP).Arquivos de neuro-psiquiatria · 2025Guideline
- Monoclonal gammopathy of undetermined significance and bone health outcomes: a systematic review and exploratory meta-analysis.Journal of bone and mineral metabolism · 2018Pooled it
- Prevalence of monoclonal gammopathy of undetermined significance: a systematic review.Mayo Clinic proceedings · 2010Pooled it
- Prediagnostic opioid use and survival in multiple myeloma: a nationwide register-based study.Scientific reports · 2026Article
- CIDP With and Without Monoclonal Gammopathy of Undetermined Significance (MGUS): Comparison of Clinical Phenotype, Diagnostic Features, and Treatment Response.Journal of the peripheral nervous system : JPNS · 2026Article
- A rare case of lepromatous leprosy in Germany.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Article
- [Clonal diseases in the border zone rheumatology/hematology].Zeitschrift fur Rheumatologie · 2025Review
- GLP-1 RA Use and Major Adverse Cardiovascular Events in Patients With Monoclonal Gammopathy of Undetermined Significance.JAMA network open · 2025Article
- Clinical Spectrum of Monoclonal Protein and the Factors Associated with Lymphoplasmacytic Malignancies.Journal of clinical medicine · 2024Article
- Trabecular Bone Score as a Complementary Tool for the Assessment of Bone Mineral Density in Patients with Asymptomatic Monoclonal Gammopathies.Journal of clinical medicine · 2024Article
- Monoclonal Gammopathy of Undetermined Significance and Associated Cardiovascular Outcomes in a Hospital Setting-A Fresh Perspective.Current oncology (Toronto, Ont.) · 2024Article
- Prevalence and distribution of M-proteins in the oncologic population affected by solid tumor.Blood cancer journal · 2024Article
- High rate of progression to symptomatic multiple myeloma in patients with smoldering myeloma and isolated osteoporotic vertebral fracture.Bone reports · 2024Article
- Discrepant serum creatinine concentrations caused by paraprotein interference preceding diagnosis of monoclonal gammopathy of undetermined significance.BMJ case reports · 2024Article
- Article
- Disease associations with monoclonal gammopathy of undetermined significance can only be evaluated using screened cohorts: results from the population-based iStopMM study.Haematologica · 2023Article
- The clinical value of monoclonal protein in ANCA-associated vasculitis with renal involvement.International urology and nephrology · 2023Article
- Risk and Severity of COVID-19 Infection in Monoclonal Gammopathy of Undetermined Significance: A 3-Year Propensity Matched Cohort Study.Clinical lymphoma, myeloma & leukemia · 2023Article
- Multimorbidity in patients with monoclonal gammopathy of undetermined significance.International journal of cancer · 2023Article
- Monoclonal gammopathy of increasing significance: time to screen?Haematologica · 2023Review
28 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo systematically study the association of monoclonal gammopathy of undetermined significance (MGUS) with all diseases in a population-based cohort of 17,398 patients, all of whom were uniformly tested for the presence or absence of MGUS. PATIENTS AND
methodsSerum samples were obtained from 77% (21,463) of the 28,038 enumerated residents in Olmsted County, Minnesota. Informed consent was obtained from patients to study 17,398 samples. Among 17,398 samples tested, 605 cases of MGUS and 16,793 negative controls were identified. The computerized Mayo Medical Index was used to obtain information on all diagnoses entered between January 1, 1975, and May 31, 2006, for a total of 422,663 person-years of observations. To identify and confirm previously reported associations, these diagnostic codes were analyzed using stratified Poisson regression, adjusting for age, sex, and total person-years of observation.
resultsWe confirmed a significant association in 14 (19%) of 75 previously reported disease associations with MGUS, including vertebral and hip fractures and osteoporosis. Systematic analysis of all 16,062 diagnostic disease codes found additional previously unreported associations, including mycobacterium infection and superficial thrombophlebitis.
conclusionThese results have major implications both for confirmed associations and for 61 diseases in which the association with MGUS is likely coincidental.
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