ArticleJournal of immunology (Baltimore, Md. : 1950)2009
C3 promotes expansion of CD8+ and CD4+ T cells in a Listeria monocytogenes infection.
Article in Journal of immunology (Baltimore, Md. : 1950), 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 39 citations in OpenAlex.
- The insider's perspective: The intracellular complosome and immune cell dynamics in cancer.Clinical and translational medicine · 2026Review
- Complement C3 deficiency enhances renal leptospiral load and inflammation while impairing T cell differentiation during chronicInfection and immunity · 2025Article
- Preclinical Study in Mouse Thymus and Thymocytes: Effects of Treatment with a Combination of Sodium Dichloroacetate and Sodium Valproate on Infectious Inflammation Pathways.Pharmaceutics · 2023Article
- More than a Pore: Nonlytic Antimicrobial Functions of Complement and Bacterial Strategies for Evasion.Microbiology and molecular biology reviews : MMBR · 2021Review
- An Immunomodulatory Transcriptional Signature Associated With PersistentFrontiers in cellular and infection microbiology · 2021Article
- Complement andFrontiers in immunology · 2021Article
- Complement andFrontiers in immunology · 2021Article
- Innate and Adaptive Immune Responses duringMicrobiology spectrum · 2019Article
- TcellSubC: An Atlas of the Subcellular Proteome of Human T Cells.Frontiers in immunology · 2019Article
- Complement C3 Produced by Macrophages Promotes Renal Fibrosis via IL-17A Secretion.Frontiers in immunology · 2018Article
- Innate and adaptive immunologic functions of complement in the host response to Listeria monocytogenes infection.Immunobiology · 2016Review
- The C5a anaphylatoxin receptor (C5aR1) protects against Listeria monocytogenes infection by inhibiting type 1 IFN expression.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Complement modulation of T cell immune responses during homeostasis and disease.Journal of leukocyte biology · 2014Review
- The receptor for the complement C3a anaphylatoxin (C3aR) provides host protection against Listeria monocytogenes-induced apoptosis.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- Septicaemia models using Streptococcus pneumoniae and Listeria monocytogenes: understanding the role of complement properdin.Medical microbiology and immunology · 2014Article
- Complement mediated signaling on pulmonary CD103(+) dendritic cells is critical for their migratory function in response to influenza infection.PLoS pathogens · 2013Article
- Complement activation is not required for obliterative airway disease induced by antibodies to major histocompatibility complex class I: Implications for chronic lung rejection.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2012Article
- Early events regulating immunity and pathogenesis during Listeria monocytogenes infection.Trends in immunology · 2012Review
- Review
- A new role of the complement system: C3 provides protection in a mouse model of lung infection with intracellular Chlamydia psittaci.PloS one · 2012Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
It is known that C3 is required for optimal expansion of T cells during acute viral infections. However, it is not yet determined whether T cell responses to intracellular bacterial infections require C3. Therefore, we have investigated the requirement for C3 to elicit potent T cell responses to Listeria monocytogenes (LM). We show that expansion of Ag-specific CD8 and CD4 T cells during a primary response to LM was markedly reduced in the absence of C3 activity. Further studies indicated that, unlike in an influenza virus infection, the regulation of LM-specific T cell responses by C3 might not involve the downstream effector C5a. Moreover, reduced T cell responses to LM was not linked to defective maturation of dendritic cells or developmental anomalies in the peripheral T cell compartment of C3-deficient mice. Experiments involving adoptive transfer of C3-deficient CD8 T cells into the C3-sufficient environment of wild-type mice showed that these T cells do not have intrinsic proliferative defects, and a paracrine source of C3 will suffice for clonal expansion of CD8 T cells in vivo. However, stimulation of purified C3-deficient CD8 T cells by plastic-immobilized anti-CD3 showed that C3 promotes T cell proliferation directly, independent of its effects on APC. On the basis of these findings, we propose that diminished T cell responses to LM in C3-deficient mice might be at least in part due to lack of direct effects of C3 on T cells. These studies have furthered our understanding of C3-mediated regulation of T cell immunity to intracellular pathogens.
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