ArticleJournal of bacteriology2009
CebR as a master regulator for cellulose/cellooligosaccharide catabolism affects morphological development in Streptomyces griseus.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Multi-proteomics reveals integrated metabolic and regulatory networks for xylan catabolism inMicrobiology spectrum · 2026Article
- A previously unidentified sugar transporter for engineering of high-yield Streptomyces.Applied microbiology and biotechnology · 2024Article
- Physiological Functions of the Cello-Oligosaccharides Binding CebE in the PathogenicMicroorganisms · 2024Article
- Article
- Phylogenomics, CAZyome and core secondary metabolome of Streptomyces albus species.Molecular genetics and genomics : MGG · 2021Article
- Mannose- and Mannobiose-Specific Responses of the Insect-Associated Cellulolytic BacteriumApplied and environmental microbiology · 2021Article
- Mining for Microbial Gems: Integrating Proteomics in the Postgenomic Natural Product Discovery Pipeline.Proteomics · 2018Review
- Carbon catabolite regulation in Streptomyces: new insights and lessons learned.World journal of microbiology & biotechnology · 2017Review
- Physiological and Molecular Understanding of Bacterial Polysaccharide Monooxygenases.Microbiology and molecular biology reviews : MMBR · 2017Review
- Evolution and Ecology of Actinobacteria and Their Bioenergy Applications.Annual review of microbiology · 2016Review
- The CebE/MsiK Transporter is a Doorway to the Cello-oligosaccharide-mediated Induction of Streptomyces scabies Pathogenicity.Scientific reports · 2016Article
- Evolution of High Cellulolytic Activity in Symbiotic Streptomyces through Selection of Expanded Gene Content and Coordinated Gene Expression.PLoS biology · 2016Article
- Nitrogen regulator GlnR controls uptake and utilization of non-phosphotransferase-system carbon sources in actinomycetes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- AraR, an l-Arabinose-Responsive Transcriptional Regulator in Corynebacterium glutamicum ATCC 31831, Exerts Different Degrees of Repression Depending on the Location of Its Binding Sites within the Three Target Promoter Regions.Journal of bacteriology · 2015Article
- Article
- Cellulolytic Streptomyces strains associated with herbivorous insects share a phylogenetically linked capacity to degrade lignocellulose.Applied and environmental microbiology · 2014Article
- Aerobic deconstruction of cellulosic biomass by an insect-associated Streptomyces.Scientific reports · 2013Article
- Article
- Potato suberin induces differentiation and secondary metabolism in the genus Streptomyces.Microbes and environments · 2012Article
- Signals and regulators that govern Streptomyces development.FEMS microbiology reviews · 2012Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Streptomyces griseus mutants exhibiting deficient glucose repression of beta-galactosidase activity on lactose-containing minimal medium supplemented with a high concentration of glucose were isolated. One of these mutants had a 12-bp deletion in cebR, which encodes a LacI/GalR family regulator. Disruption of cebR in the wild-type strain caused the same phenotype as the mutant, indicating that CebR is required for glucose repression of beta-galactosidase activity. Recombinant CebR protein bound to a 14-bp inverted-repeat sequence (designated the CebR box) present in the promoter regions of cebR and the putative cellobiose utilization operon, cebEFG-bglC. The DNA-binding activity of CebR was impaired by cellooligosaccharides, including cellobiose, cellotriose, cellotetraose, cellopentaose, and cellohexaose. In agreement with this observation, transcription from the cebE and cebR promoters was greatly enhanced by the addition of cellobiose to the medium. Seven other genes containing one or two CebR boxes in their upstream regions were found in the S. griseus genome. Five of these genes encode putative secreted proteins: two cellulases, a cellulose-binding protein, a pectate lyase, and a protein of unknown function. These five genes and cebEFG-bglC were transcribed at levels 4 to 130 times higher in the DeltacebR mutant than in the wild-type strain, as determined by quantitative reverse transcription-PCR. These findings indicate that CebR is a master regulator of cellulose/cellooligosaccharide catabolism. Unexpectedly, the DeltacebR mutant formed very few aerial hyphae on lactose-containing medium, demonstrating a link between carbon source utilization and morphological development.
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