ArticleJournal of bacteriology2009
Flagellar formation in C-ring-defective mutants by overproduction of FliI, the ATPase specific for flagellar type III secretion.
Article in Journal of bacteriology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed.
- A novel two-component system contributing the catabolism of c-di-GMP influences virulence inFrontiers in microbiology · 2025Article
- Article
- Twists and turns: 40 years of investigating how and why bacteria swim.Microbiology (Reading, England) · 2024Review
- High-Throughput Transcriptomic Profiling Reveals the Inhibitory Effect of Hydroquinine on Virulence Factors inAntibiotics (Basel, Switzerland) · 2022Article
- Article
- Switching and Torque Generation in SwarmingFrontiers in microbiology · 2018Article
- An intrinsically disordered linker controlling the formation and the stability of the bacterial flagellar hook.BMC biology · 2017Article
- Functional Characterization of EscK (Orf4), a Sorting Platform Component of the Enteropathogenic Escherichia coli Injectisome.Journal of bacteriology · 2017Article
- Structural insights into bacterial flagellar hooks similarities and specificities.Scientific reports · 2016Article
- A working model for the type III secretion mechanism in Chlamydia.Microbes and infection · 2016Review
- Type III secretion systems: the bacterial flagellum and the injectisome.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Composition, formation, and regulation of the cytosolic c-ring, a dynamic component of the type III secretion injectisome.PLoS biology · 2015Article
- Interaction of the extreme N-terminal region of FliH with FlhA is required for efficient bacterial flagellar protein export.Journal of bacteriology · 2012Article
- Mystery of fliK in length control of the flagellar hook.Journal of bacteriology · 2012Article
- Protein export according to schedule: architecture, assembly, and regulation of type III secretion systems from plant- and animal-pathogenic bacteria.Microbiology and molecular biology reviews : MMBR · 2012Review
- Loss of FlhE in the flagellar Type III secretion system allows proton influx into Salmonella and Escherichia coli.Molecular microbiology · 2012Article
- HrcQ provides a docking site for early and late type III secretion substrates from Xanthomonas.PloS one · 2012Article
- Quantitative proteomics reveals metabolic and pathogenic properties of Chlamydia trachomatis developmental forms.Molecular microbiology · 2011Article
- An infrequent molecular ruler controls flagellar hook length in Salmonella enterica.The EMBO journal · 2011Article
- The flagellar protein FliL is essential for swimming in Rhodobacter sphaeroides.Journal of bacteriology · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
The flagellar cytoplasmic ring (C ring), which consists of three proteins, FliG, FliM, and FliN, is located on the cytoplasmic side of the flagellum. The C ring is a multifunctional structure necessary for flagellar protein secretion, torque generation, and switching of the rotational direction of the motor. The deletion of any one of the fliG, fliM, and fliN genes results in a Fla(-) phenotype. Here, we show that the overproduction of the flagellum-specific ATPase FliI overcomes the inability of basal bodies with partial C-ring structures to produce complete flagella. Flagella made upon FliI overproduction were paralyzed, indicating that an intact C ring is essential for motor function. In FliN- or FliM-deficient mutants, flagellum production was about 10% of the wild-type level, while it was only a few percent in FliG-deficient mutants, suggesting that the size of partial C rings affects the extent of flagellation. For flagella made in C-ring mutants, the hook length varied considerably, with many being markedly shorter or longer than that of the wild type. The broad distribution of hook lengths suggests that defective C rings cannot control the hook length as tightly as the wild type even though FliK and FlhB are both intact.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.