ArticleVirology2009
Investigation of the impact of the common animal facility contaminant murine norovirus on experimental murine cytomegalovirus infection.
Article in Virology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 17 citations in OpenAlex.
- Lack of Effect of Murine Norovirus Infection on the CD4Comparative medicine · 2020Article
- Interferon-λ3 Promotes Epithelial Defense and Barrier Function Against Cryptosporidium parvum Infection.Cellular and molecular gastroenterology and hepatology · 2019Article
- Histologic Lesions Induced by Murine Norovirus Infection in Laboratory Mice.Veterinary pathology · 2016Review
- Viruses in Rodent Colonies: Lessons Learned from Murine Noroviruses.Annual review of virology · 2015Review
- Protective role of murine norovirus against Pseudomonas aeruginosa acute pneumonia.Veterinary research · 2015Article
- Effects of murine norovirus on atherosclerosis in ldlr(-/-) mice depends on the timing of infection.Comparative medicine · 2015Article
- Detection of murine norovirus by reverse transcription loop-mediated isothermal amplification.Journal of virological methods · 2014Article
- Infection with murine norovirus 4 does not alter Helicobacter-induced inflammatory bowel disease in Il10(-/-) mice.Comparative medicine · 2014Article
- A broadly reactive one-step SYBR Green I real-time RT-PCR assay for rapid detection of murine norovirus.PloS one · 2014Article
- Norovirus regulation of the innate immune response and apoptosis occurs via the product of the alternative open reading frame 4.PLoS pathogens · 2011Article
- Eliminating murine norovirus by cross-fostering.Journal of the American Association for Laboratory Animal Science : JAALAS · 2011Article
- Lack of effect of murine norovirus infection on a mouse model of bacteria-induced colon cancer.Comparative medicine · 2011Article
- Transient or persistent norovirus infection does not alter the pathology of Salmonella typhimurium induced intestinal inflammation and fibrosis in mice.Comparative immunology, microbiology and infectious diseases · 2011Article
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Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Murine norovirus (MNV) is a recently discovered pathogen that has become a common contaminant of specific pathogen-free mouse colonies. MNV-1 induces a robust interferon-beta response and causes histopathology in some mouse strains, suggesting that it may impact other mouse models of infection. Despite many concerns about MNV-1 contamination, there is little information about its impact on immune responses to other infections. This study addresses whether MNV-1 infection has an effect on a model of murine cytomegalovirus (MCMV) infection. Exposure to MNV-1 resulted in a decreased CD8 T cell response to immunodominant MCMV epitopes in both BALB/c and C57BL/6 mice. However, MNV-1 did not impact MCMV titers in either mouse strain, nor did it stimulate reactivation of latent MCMV. These data suggest that while MNV-1 has a mild impact on the immune response to MCMV, it is not likely to affect most experimental outcomes in immunocompetent mice in the MCMV model.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.