ArticleBone2009
The dependency of solute diffusion on molecular weight and shape in intact bone.
Article in Bone, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 49 citations in OpenAlex.
- Osteocyte-Derived Extracellular Vesicles: Bridging the Gap in Skeletal Physiology and Pathophysiology.Current osteoporosis reports · 2026Review
- Harnessing agent-based frameworks in CellAgentChat to unravel cell-cell interactions from single-cell and spatial transcriptomics.Genome research · 2025Article
- Article
- Article
- Article
- Changes in the intra- and peri-cellular sclerostin distribution in lacuno-canalicular system induced by mechanical unloading.Journal of bone and mineral metabolism · 2021Article
- Molecular Signaling Interactions and Transport at the Osteochondral Interface: A Review.Frontiers in cell and developmental biology · 2020Review
- Elevated solute transport at sites of diffuse matrix damage in cortical bone: Implications on bone repair.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- Solute Transport in the Bone Lacunar-Canalicular System (LCS).Current osteoporosis reports · 2018Review
- Article
- Pannexin-1 and P2X7-Receptor Are Required for Apoptotic Osteocytes in Fatigued Bone to Trigger RANKL Production in Neighboring Bystander Osteocytes.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2016Article
- A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone.Bone research · 2016Article
- Imaging and quantifying solute transport across periosteum: implications for muscle-bone crosstalk.Bone · 2014Article
- Article
- Perlecan-containing pericellular matrix regulates solute transport and mechanosensing within the osteocyte lacunar-canalicular system.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- Osteocytes: master orchestrators of bone.Calcified tissue international · 2014Review
- Quantifying load-induced solute transport and solute-matrix interaction within the osteocyte lacunar-canalicular system.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2013Article
- Advances in assessment of bone porosity, permeability and interstitial fluid flow.Journal of biomechanics · 2013Review
- Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
Solute transport through the bone lacunar-canalicular system (LCS) is essential for osteocyte survival and function, but quantitative data on the diffusivity of various biological molecules in the LCS are scarce. Using our recently developed approach based on fluorescence recovery after photobleaching (FRAP), diffusion coefficients of five exogenous fluorescent tracers (sodium fluorescein, dextran-3k, dextran-10k, parvalbumin, and ovalbumin) were measured in murine tibiae in situ. These tracers were chosen to test the dependency of solute diffusion on molecular weight (376-43,000 Da) and shape (linear vs. globular). Among the five tracers, no fluorescence recovery (and thus mobility) was detected for dextran-10k and the diffusion coefficients (D(LCS)) of the other four tracers were 295+/-46, 128+/-32, 157+/-88, 65+/-21 microm(2) s(-1) in the LCS, respectively. Overall, the rate of solute diffusion in the bone LCS showed strong dependency on molecular size and shape. Diffusivity decreased with increasing molecular weight for both linear and globular molecules, with the linear molecules decreasing at a faster rate. Compared with free diffusion (D(free)) in aqueous solutions, the relative diffusivities (D(LCS)/D(free)) of the four tracers were not significantly different for sodium fluorescein, dextran-3k, parvalbumin, and ovalbumin (55.0+/-8.6%, 68.1+/-17.0%, 79.7+/-44.7%, 61.0+/-19.6%, respectively). This result did not agree with the homogenous molecular sieve model proposed for the osteocytic pericellular matrix structure. Instead, a heterogeneous porous model of the pericellular matrix may account for the observed solute transport in the LCS. In summary, the present study provides quantitative data on diffusion of various nutrients and signaling molecules in the LCS that are important for bone metabolism and mechanotransduction.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.