ArticleNeuroscience letters2009
Mechanical loading of a long bone induces plasticity in sensory input to the central nervous system.
Article in Neuroscience letters, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Sensory nerves regulate bone homeostasis in response to mechanical unloading or reloading: evidence from a spaceflight experiment and ground-based mechanical unloading models.Bone research · 2026Article
- Skeletal interoception in bone homeostasis and pain.Cell metabolism · 2022Review
- Biological basis of bone strength: anatomy, physiology and measurement.Journal of musculoskeletal & neuronal interactions · 2020Review
- The Role of Nerves in Skeletal Development, Adaptation, and Aging.Frontiers in endocrinology · 2020Review
- Assessment of acute bone loading in humans using [European journal of nuclear medicine and molecular imaging · 2019Article
- Peripheral Neuropathy as a Component of Skeletal Disease in Diabetes.Current osteoporosis reports · 2019Review
- Nerves in Bone: Evolving Concepts in Pain and Anabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading.PloS one · 2018Article
- Mechanical basis of bone strength: influence of bone material, bone structure and muscle action.Journal of musculoskeletal & neuronal interactions · 2017Review
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- Evolving concepts in neurogenic osteoporosis.Current osteoporosis reports · 2010Review
- Systemic effects of ulna loading in male rats during functional adaptation.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2010Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Although the skeleton is extensively innervated by sensory nerves, the importance of this innervation to skeletal physiology is unclear. Neuronal connectivity between limbs is little studied and likely underestimated. In this study, we examined the effect of bone loading on spinal plasticity in young male Sprague-Dawley rats, using end-loading of the ulna and transynaptic tracing with the Bartha pseudorabies virus (PRV). PRV was inoculated onto the periosteum of the right ulna after 10 days of adaptation to a single period of cyclic loading of the right ulna (1,500 cycles of load at 4 Hz, initial peak strain of -3,750 micro epsilon). We found that neuronal circuits connect the sensory innervation of right thoracic limb to all other limbs, as PRV was detectable in the dorsal root ganglia (DRG) of left and right brachial and lumbosacral intumescences. We also found that mechanical loading of the right ulna induced plasticity in the spinal cord, with significant augmentation of the connectivity between limbs, as measured by PRV translocation. Within the spinal cord, PRV was predominantly found adjacent to the central canal and in the dorsal horns, suggesting that plasticity in cross-talk between limbs is likely a consequence of dendritic growth, and enhanced connectivity of propriospinal interneurons. In conclusion, the data clearly demonstrate that the innervation of the skeleton exhibits plasticity in response to loading events, suggesting the existence of a dynamic control system that may be of regulatory importance during functional skeletal adaptation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.