ArticleDevelopmental biology2009
Spots and stripes: pleomorphic patterning of stem cells via p-ERK-dependent cell chemotaxis shown by feather morphogenesis and mathematical simulation.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 69 citations in OpenAlex.
- Roles of K-channel activity in feather bud morphogenesis.Developmental biology · 2026Article
- Embryonic Avian Skin Explant Cultures: A Versatile Model for Investigating Tissue Patterning Mechanisms.The Journal of investigative dermatology · 2025Review
- Organizational principles of integumentary organs: Maximizing variations for effective adaptation.Developmental biology · 2025Review
- Skin regional specification and higher-orderScience advances · 2025Article
- Gap junctions in Turing-type periodic feather pattern formation.PLoS biology · 2024Article
- Periodic pattern formation during embryonic development.Biochemical Society transactions · 2024Review
- A shark-inspired general model of tooth morphogenesis unveils developmental asymmetries in phenotype transitions.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Cell shape anisotropy contributes to self-organized feather pattern fidelity in birds.PLoS biology · 2022Article
- Parameterized Computational Framework for the Description and Design of Genetic Circuits of Morphogenesis Based on Contact-Dependent Signaling and Changes in Cell-Cell Adhesion.ACS synthetic biology · 2022Article
- Symmetry breaking in the embryonic skin triggers directional and sequential plumage patterning.PLoS biology · 2019Article
- Synthetic development: building mammalian multicellular structures with artificial genetic programs.Current opinion in biotechnology · 2019Review
- STOCHASTIC DYNAMICS OF CELL LINEAGE IN TISSUE HOMEOSTASIS.Discrete and continuous dynamical systems. Series B · 2019Article
- Self-organizing hair peg-like structures from dissociated skin progenitor cells: New insights for human hair follicle organoid engineering and Turing patterning in an asymmetric morphogenetic field.Experimental dermatology · 2019Article
- Turing patterning with and without a global wave.PLoS biology · 2019Article
- Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.Nature communications · 2018Article
- Hair follicle dermal condensation forms via Fgf20 primed cell cycle exit, cell motility, and aggregation.eLife · 2018Article
- Article
- Genomic determinants of epidermal appendage patterning and structure in domestic birds.Developmental biology · 2017Article
- Hierarchical patterning modes orchestrate hair follicle morphogenesis.PLoS biology · 2017Article
- A spectrum of modularity in multi-functional gene circuits.Molecular systems biology · 2017Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
Abstract
A key issue in stem cell biology is the differentiation of homogeneous stem cells towards different fates which are also organized into desired configurations. Little is known about the mechanisms underlying the process of periodic patterning. Feather explants offer a fundamental and testable model in which multi-potential cells are organized into hexagonally arranged primordia and the spacing between primordia. Previous work explored roles of a Turing reaction-diffusion mechanism in establishing chemical patterns. Here we show that a continuum of feather patterns, ranging from stripes to spots, can be obtained when the level of p-ERK activity is adjusted with chemical inhibitors. The patterns are dose-dependent, tissue stage-dependent, and irreversible. Analyses show that ERK activity-dependent mesenchymal cell chemotaxis is essential for converting micro-signaling centers into stable feather primordia. A mathematical model based on short-range activation, long-range inhibition, and cell chemotaxis is developed and shown to simulate observed experimental results. This generic cell behavior model can be applied to model stem cell patterning behavior at large.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.