Evidence map›Paper›PMID 19647511›Full record

ArticleMolecular cell2009

Ras and the FAK paradox.

Marc A Antonyak, Richard A Cerione

Abstract readComment
In one paragraph

Article in Molecular cell, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors.

Marc A AntonyakDepartment of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA.
Richard A Cerione

Funding

Roles of Cdc42 and its signaling partners in cell growth and differentiationR01GM047458 · NIGMS · CORNELL UNIVERSITY ITHACA · PI CERIONE, RICHARD A. · 1992 to 2016
$5.6M
RECONSTITUTION OF GROWTH FACTOR RECEPTOR/TYROSINE KINASER01GM040654 · NIGMS · CORNELL UNIVERSITY ITHACA · PI CERIONE, RICHARD A. · 1988 to 2016
$5.6M
Role of GTP-binding/transglutaminase in cell survival and migrationR01GM061762 · NIGMS · CORNELL UNIVERSITY ITHACA · PI CERIONE, RICHARD A. · 2000 to 2011
$3.1M
NIGMS NIH HHS R01 GM040654NIGMS NIH HHS R01 GM047458NIGMS NIH HHS R01 GM061762
6 · The paper itself

Abstract

In a recent issue of Molecular Cell, Zheng et al. (2009) describe a surprising set of findings that highlight an unexpected negative regulation of FAK by oncogenic Ras and its consequences for cancer cell migration and invasion.

Indexed as

AnimalsCell MovementEnzyme ActivationFocal Adhesion Protein-Tyrosine KinasesMiceModels, BiologicalNeoplasm MetastasisPhosphorylationras ProteinsSignal TransductionFocal Adhesion Protein-Tyrosine Kinasesras Proteins

Identifiers

PMID19647511
PMCPMC3065190

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.