Evidence map›Paper›PMID 19646895›Full record

ReviewTrends in endocrinology and metabolism: TEM2009

Role of Dicer in female fertility.

Lacey J Luense, Martha Z Carletti, Lane K Christenson

Open access · greenAbstract readReview
In one paragraph

Review in Trends in endocrinology and metabolism: TEM, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 1 synthesis or guideline pooled it, 98 citations in OpenAlex.

  1. Pooled it
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  18. Article
  19. Article
  20. MicroRNA in Ovarian Biology and Disease.Cold Spring Harbor perspectives in medicine · 2015
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lacey J LuenseDepartment of Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, KS 66160, USA.
Martha Z Carletti
Lane K Christenson
University of Kansas Medical Center · US

Funding

Post-transcriptional gene regulation in the ovaryR21HD051870 · NICHD · UNIVERSITY OF KANSAS MEDICAL CENTER · PI CHRISTENSON, LANE K · 2006 to 2007
$359k
NICHD NIH HHS HD051870NICHD NIH HHS R21 HD051870
6 · The paper itself

Abstract

Dicer is an RNAse III endonuclease that is essential for the biogenesis of microRNAs and small interfering RNAs. These small RNAs post-transcriptionally regulate mRNA gene expression through several mechanisms to affect key cellular events including proliferation, differentiation and apoptosis. Recently, the role of Dicer function in female reproductive tissues has begun to be elucidated through the use of knockout mouse models. Loss of Dicer within ovarian granulosa cells, luteal tissue, oocyte, oviduct and, potentially, the uterus renders females infertile. This review discusses these early studies and other data describing the current understanding of microRNAs and small interfering RNAs in female reproduction.

Indexed as

Gene Expression RegulationAnimalsEmbryo, MammalianFallopian TubesFemaleFertilityHumansInfertility, FemaleMiceMice, KnockoutMicroRNAsOocytesOrgan SpecificityOvarian FolliclePregnancyRibonuclease IIIMicroRNAsRibonuclease IIIRNA, Small Interfering

Identifiers

PMID19646895
PMCPMC3121329
OpenAlexW2159161155

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.