ArticleCellular immunology2009
CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Article in Cellular immunology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 17 citations in OpenAlex.
- Mechanisms of T cell activation: Integrating signaling pathways, experimental models, and therapeutic implications.EXCLI journal · 2026Review
- Co-stimulatory and co-inhibitory pathways in cancer immunotherapy.Advances in cancer research · 2019Review
- B cells regulate CD4+ T cell responses to papain following B cell receptor-independent papain uptake.Journal of immunology (Baltimore, Md. : 1950) · 2014Article
- T cell co-stimulatory molecules: a co-conspirator in the pathogenesis of eosinophilic esophagitis?Digestive diseases and sciences · 2013Review
- ICOS-expressing lymphocytes promote resolution of CD8-mediated lung injury in a mouse model of lung rejection.PloS one · 2013Article
- Inducible costimulator controls migration of T cells to the lungs via down-regulation of CCR7 and CD62L.American journal of respiratory cell and molecular biology · 2011Article
- Endogenous matrix metalloproteinases 2 and 9 regulate activation of CD4+ and CD8+ T cells.American journal of respiratory cell and molecular biology · 2011Article
- T-cell costimulatory molecules in acute-graft-versus host disease: therapeutic implications.Bone marrow research · 2011Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 1 country.
Funding
Abstract
Previous work has shown ICOS can function independently of CD28, but whether either molecule can compensate for the other in vivo is not known. Since ICOS is a potent inducer of Th2 cytokines and linked to allergy and elevated serum IgE in humans, we hypothesized that augmenting ICOS costimulation in murine allergic airway disease may overcome CD28 deficiency. While ICOS was expressed on T cells from CD28(-/-) mice, Th2-mediated airway inflammation was not induced in CD28(-/-) mice by increased ICOS costimulation. Further, we determined if augmenting CD28 costimulation could compensate for ICOS deficiency. ICOS(-/-) mice had a defect in airway eosinophilia that was not overcome by augmenting CD28 costimulation. CD28 costimulation also did not fully compensate for ICOS for antibody responses, germinal center formation or the development of follicular B helper T cells. CD28 and ICOS play complementary non-overlapping roles in the development of Th2 immunity in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.