ArticleAmerican journal of human genetics2009
Skewed X chromosome inactivation and trisomic spontaneous abortion: no association.
Article in American journal of human genetics, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 91 citations in OpenAlex.
- Identification and functional analysis of a novel de novo missense mutation located in the initiation codon of LAMP2 associated with early onset female Danon disease.Molecular genetics & genomic medicine · 2023Article
- Expanding the Spectrum ofGenes · 2022Article
- Investigation of the role of X chromosome inactivation and androgen receptor CAG repeat polymorphisms in patients with recurrent pregnancy loss: a prospective case-control study.BMC pregnancy and childbirth · 2022Article
- Intermediate CGG repeat length at the FMR1 locus is not associated with hormonal indicators of ovarian age.Menopause (New York, N.Y.) · 2014Article
- Trisomic pregnancy and intermediate CGG repeat length at the FMR1 locus.Human reproduction (Oxford, England) · 2012Article
- Copy number changes on the X chromosome in women with and without highly skewed X-chromosome inactivation.Cytogenetic and genome research · 2012Article
- Genetics of recurrent miscarriage: challenges, current knowledge, future directions.Frontiers in genetics · 2012Article
- Using FISH to increase the yield and accuracy of karyotypes from spontaneous abortion specimens.Prenatal diagnosis · 2011Article
- Trisomic pregnancy and elevated FSH: implications for the oocyte pool hypothesis.Human reproduction (Oxford, England) · 2011Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Several studies suggest that highly skewed X chromosome inactivation (HSXI) is associated with recurrent spontaneous abortion. We hypothesized that this association reflects an increased rate of trisomic conceptions due to anomalies on the X chromosome that lead both to HSXI and to a diminished oocyte pool. We compared the distribution of X chromosome inactivation (XCI) skewing percentages (range: 50%-100%) among women with spontaneous abortions in four karyotype groups-trisomy (n = 154), chromosomally normal male (n = 43), chromosomally normal female (n = 38), nontrisomic chromosomally abnormal (n = 61)-to the distribution for age-matched controls with chromosomally normal births (n = 388). In secondary analyses, we subdivided the nontrisomic chromosomally abnormal group, divided trisomies by chromosome, and classified women by reproductive history. Our data support neither an association of HSXI with all trisomies nor an association of HSXI with chromosomally normal male spontaneous abortions. We also find no association between HSXI and recurrent abortion (n = 45).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.