ArticleBMC evolutionary biology2009
The sea lamprey Petromyzon marinus genome reveals the early origin of several chemosensory receptor families in the vertebrate lineage.
Article in BMC evolutionary biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 71 citations in OpenAlex.
- Vertebrate-wide transcriptomic screening identifies immune cell-specific expression of the conserved OR-κ gene.Zoological letters · 2026Article
- Hagfish olfactory repertoire illuminates lineage-specific diversification of olfaction in basal vertebrates.iScience · 2025Article
- Chemosensation of the pheromone spermine by the olfactory TAAR-like receptor TAAR348.Cell discovery · 2025Article
- Behavioral, Endocrine, and Neuronal Responses to Odors in Lampreys.Animals : an open access journal from MDPI · 2025Review
- Type 2 vomeronasal receptor expression in the olfactory organ of African lungfish, Protopterus annectens.Cell and tissue research · 2024Article
- Ancient and Nonuniform Loss of Olfactory Receptor Expression Renders the Shark Nose a De Facto Vomeronasal Organ.Molecular biology and evolution · 2023Article
- Evolution of Brain-Expressed Biogenic Amine Receptors into Olfactory Trace Amine-Associated Receptors.Molecular biology and evolution · 2022Article
- Olfactory-induced locomotion in lampreys.Cell and tissue research · 2022Review
- Olfactory function in the trace amine-associated receptor family (TAARs) evolved twice independently.Scientific reports · 2021Article
- Olfactory signaling via trace amine-associated receptors.Cell and tissue research · 2021Review
- Coding of pheromones by vomeronasal receptors.Cell and tissue research · 2021Review
- The evolutionary origins of the vertebrate olfactory system.Open biology · 2020Review
- Two highly related odorant receptors specifically detect α-bile acid pheromones in sea lamprey (The Journal of biological chemistry · 2020Article
- TAAR Agonists.Cellular and molecular neurobiology · 2020Review
- Transcriptional Basis of Copper-Induced Olfactory Impairment in the Sea Lamprey, a Primitive Invasive Fish.G3 (Bethesda, Md.) · 2019Article
- The Chemosensory Receptor Repertoire of a True Shark Is Dominated by a Single Olfactory Receptor Family.Genome biology and evolution · 2019Article
- Nitrogenous compounds characterized in the deterrent skin extract of migratory adult sea lamprey from the Great Lakes region.PloS one · 2019Article
- Putative chemosensory receptors are differentially expressed in the sensory organs of male and female crown-of-thorns starfish, Acanthaster planci.BMC genomics · 2018Article
- Excreted Steroids in Vertebrate Social Communication.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Review
- Enabling the hypothesis-driven prioritization of ligand candidates in big databases: Screenlamp and its application to GPCR inhibitor discovery for invasive species control.Journal of computer-aided molecular design · 2018Article
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn gnathostomes, chemosensory receptors (CR) expressed in olfactory epithelia are encoded by evolutionarily dynamic gene families encoding odorant receptors (OR), trace amine-associated receptors (TAAR), V1Rs and V2Rs. A limited number of OR-like sequences have been found in invertebrate chordate genomes. Whether these gene families arose in basal or advanced vertebrates has not been resolved because these families have not been examined systematically in agnathan genomes.
resultsPetromyzon is the only extant jawless vertebrate whose genome has been sequenced. Known to be exquisitely sensitive to several classes of odorants, lampreys detect fewer amino acids and steroids than teleosts. This reduced number of detectable odorants is indicative of reduced numbers of CR gene families or a reduced number of genes within CR families, or both, in the sea lamprey. In the lamprey genome we identified a repertoire of 59 intact single-exon CR genes, including 27 OR, 28 TAAR, and four V1R-like genes. These three CR families were expressed in the olfactory organ of both parasitic and adult life stages.
conclusionAn extensive search in the lamprey genome failed to identify potential orthologs or pseudogenes of the multi-exon V2R family that is greatly expanded in teleost genomes, but did find intact calcium-sensing receptors (CASR) and intact metabotropic glutamate receptors (MGR). We conclude that OR and V1R arose in chordates after the cephalochordate-urochordate split, but before the diversification of jawed and jawless vertebrates. The advent and diversification of V2R genes from glutamate receptor-family G protein-coupled receptors, most likely the CASR, occurred after the agnathan-gnathostome divergence.
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