ArticleGenome biology2009
Zebrafish reward mutants reveal novel transcripts mediating the behavioral effects of amphetamine.
Article in Genome biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.
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Who cites it
34 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Neuronal development genes are key elements mediating the reinforcing effects of methamphetamine, amphetamine, and methylphenidate.Psychopharmacology · 2013Pooled it
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- A Mini-Review Regarding the Modalities to Study Neurodevelopmental Disorders-Like Impairments in Zebrafish-Focussing on Neurobehavioural and Psychological Responses.Brain sciences · 2022Review
- Translational relevance of forward genetic screens in animal models for the study of psychiatric disease.Neuroscience and biobehavioral reviews · 2022Review
- Larval Zebrafish as a Model for Mechanistic Discovery in Mental Health.Frontiers in molecular neuroscience · 2022Review
- A Novel Precision Approach to Overcome the "Addiction Pandemic" by Incorporating Genetic Addiction Risk Severity (GARS) and Dopamine Homeostasis Restoration.Journal of personalized medicine · 2021Review
- A Review of the Functional Roles of the Zebrafish Aryl Hydrocarbon Receptors.Toxicological sciences : an official journal of the Society of Toxicology · 2020Review
- The Role of Zebrafish and Laboratory Rodents in Schizophrenia Research.Frontiers in psychiatry · 2020Review
- D-Amphetamine Exposure Differentially Disrupts Signaling Across Ontogeny in the Zebrafish.Bioelectricity · 2019Article
- Adult zebrafish in CNS disease modeling: a tank that's half-full, not half-empty, and still filling.Lab animal · 2017Article
- Pharmacological analyses of learning and memory in zebrafish (Danio rerio).Pharmacology, biochemistry, and behavior · 2015Review
- Large-scale live imaging of adult neural stem cells in their endogenous niche.Development (Cambridge, England) · 2015Article
- Molecular psychiatry of zebrafish.Molecular psychiatry · 2015Article
- Neurochemical measurements in the zebrafish brain.Frontiers in behavioral neuroscience · 2015Article
- Body Mass Parameters, Lipid Profiles and Protein Contents of Zebrafish Embryos and Effects of 2,4-Dinitrophenol Exposure.PloS one · 2015Article
- Emotions and motivated behavior converge on an amygdala-like structure in the zebrafish.The European journal of neuroscience · 2014Article
- Article
- The influences of parental diet and vitamin E intake on the embryonic zebrafish transcriptome.Comparative biochemistry and physiology. Part D, Genomics & proteomics · 2014Article
- Perspectives on zebrafish models of hallucinogenic drugs and related psychotropic compounds.ACS chemical neuroscience · 2013Review
- Behavioral effects of bidirectional modulators of brain monoamines reserpine and d-amphetamine in zebrafish.Brain research · 2013Article
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAddiction is a pathological dysregulation of the brain's reward systems, determined by several complex genetic pathways. The conditioned place preference test provides an evaluation of the effects of drugs in animal models, allowing the investigation of substances at a biologically relevant level with respect to reward. Our lab has previously reported the development of a reliable conditioned place preference paradigm for zebrafish. Here, this test was used to isolate a dominant N-ethyl-N-nitrosourea (ENU)-induced mutant, no addiction (nad(dne3256)), which fails to respond to amphetamine, and which we used as an entry point towards identifying the behaviorally relevant transcriptional response to amphetamine.
resultsThrough the combination of microarray experiments comparing the adult brain transcriptome of mutant and wild-type siblings under normal conditions, as well as their response to amphetamine, we identified genes that correlate with the mutants' altered conditioned place preference behavior. In addition to pathways classically involved in reward, this gene set shows a striking enrichment in transcription factor-encoding genes classically involved in brain development, which later appear to be re-used within the adult brain. We selected a subset of them for validation by quantitative PCR and in situ hybridization, revealing that specific brain areas responding to the drug through these transcription factors include domains of ongoing adult neurogenesis. Finally, network construction revealed functional connections between several of these genes.
conclusionsTogether, our results identify a new network of coordinated gene regulation that influences or accompanies amphetamine-triggered conditioned place preference behavior and that may underlie the susceptibility to addiction.
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