Evidence map›Paper›PMID 19645074›Full record

ReviewHematological oncology2010

The root of many evils: indolent large granular lymphocyte leukaemia and associated disorders.

Ranran Zhang, Mithun Vinod Shah, Thomas P Loughran

Abstract readReview
In one paragraph

Review in Hematological oncology, 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

41 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. The Significance of the Microenvironment in T/Nk-Cell Neoplasms.International journal of molecular sciences · 2025
    Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Frontiers in medicine · 2022
    Article
  13. Review
  14. Review
  15. Large granular lymphocytic leukemia: a brief review.American journal of blood research · 2022
    Review
  16. Article
  17. Review
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Ranran ZhangPenn State Hershey Cancer Institute, The Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Mithun Vinod Shah
Thomas P Loughran

Funding

Survival Mechanisms in Leukemic NK CellsR01CA098472 · NCI · UNIVERSITY OF VIRGINIA · PI LOUGHRAN, THOMAS P. · 2003 to 2016
$4.0M
NCI NIH HHS CA 94872NCI NIH HHS R01 CA098472
6 · The paper itself

Abstract

Large granular lymphocytes (LGL) leukaemia can arise from either natural killer (NK) cells or cytotoxic T lymphocytes (CTL). The T-cell form of LGL leukaemia has significant overlap with other haematological disorders and autoimmune diseases. Here we provide an overview of LGL biology. We also focus discussion on the indolent LGL leukaemia related disorders and their causal relationships. We then discuss the potential relationships and distinctions between indolent LGL leukaemia and non-malignant clonal lymphocyte expansion that occur in otherwise healthy individuals, especially elder people.

Indexed as

HumansKiller Cells, NaturalLeukemia, Large Granular LymphocyticLymphocytes

Identifiers

PMID19645074
PMCPMC4377226

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.