ArticleArthritis and rheumatism2009
European population substructure is associated with mucocutaneous manifestations and autoantibody production in systemic lupus erythematosus.
Article in Arthritis and rheumatism, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients.PloS one · 2018Trial
- Review
- Complement Properdin Determines Disease Activity in MRL/Medicina (Kaunas, Lithuania) · 2020Article
- Genome-Wide Association Analysis Reveals Genetic Heterogeneity of Sjögren's Syndrome According to Ancestry.Arthritis & rheumatology (Hoboken, N.J.) · 2017Article
- The genetics of human autoimmune disease: A perspective on progress in the field and future directions.Journal of autoimmunity · 2015Review
- Ethnicity-specific epigenetic variation in naïve CD4+ T cells and the susceptibility to autoimmunity.Epigenetics & chromatin · 2015Article
- DNA methylation patterns in naïve CD4+ T cells identify epigenetic susceptibility loci for malar rash and discoid rash in systemic lupus erythematosus.Lupus science & medicine · 2015Article
- Lack of replication of higher genetic risk load in men than in women with systemic lupus erythematosus.Arthritis research & therapy · 2014Article
- Systemic lupus erythematosus diagnostics in the 'omics' era.International journal of clinical rheumatology · 2013Article
- Bias in effect size of systemic lupus erythematosus susceptibility loci across Europe: a case-control study.Arthritis research & therapy · 2012Article
- Further evidence of subphenotype association with systemic lupus erythematosus susceptibility loci: a European cases only study.PloS one · 2012Article
- Stronger bone correlates with African admixture in African-American women.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2011Article
- Association of increased serum IL-33 levels with clinical and laboratory characteristics of systemic lupus erythematosus in Chinese population.Clinical and experimental medicine · 2011Article
- Association of systemic lupus erythematosus clinical features with European population genetic substructure.PloS one · 2011Article
- European population substructure correlates with systemic lupus erythematosus endophenotypes in North Americans of European descent.Genes and immunity · 2010Article
- Using genetics to deliver personalized SLE therapy-a realistic prospect?Nature reviews. Rheumatology · 2010Review
- Biomarkers as tools for improved diagnostic and therapeutic monitoring in systemic lupus erythematosis.Arthritis research & therapy · 2009Review
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24 authors.
Funding
Abstract
objectiveTo determine whether genetic substructure in European-derived populations is associated with specific manifestations of systemic lupus erythematosus (SLE), including mucocutaneous phenotypes, autoantibody production, and renal disease.
methodsSLE patients of European descent (n=1,754) from 8 case collections were genotyped for >1,400 ancestry informative markers that define a north-south gradient of European substructure. Using the Structure program, each SLE patient was characterized in terms of percent Northern (versus percent Southern) European ancestry based on these genetic markers. Nonparametric methods, including tests for trend, were used to identify associations between Northern European ancestry and specific SLE manifestations.
resultsIn multivariate analyses, increasing levels of Northern European ancestry were significantly associated with photosensitivity (Ptrend=0.0021, odds ratio for highest quartile of Northern European ancestry versus lowest quartile [ORhigh-low] 1.64, 95% confidence interval [95% CI] 1.13-2.35) and discoid rash (Ptrend=0.014, ORhigh-low 1.93, 95% CI 0.98-3.83). In contrast, increasing levels of Northern European ancestry had a protective effect against the production of anticardiolipin autoantibodies (Ptrend=1.6x10(-4), ORhigh-low 0.46, 95% CI 0.30-0.69) and anti-double-stranded DNA autoantibodies (Ptrend=0.017, ORhigh-low 0.67, 95% CI 0.46-0.96).
conclusionThis study demonstrates that specific SLE manifestations vary according to Northern versus Southern European ancestry. Thus, genetic ancestry may contribute to the clinical heterogeneity and variation in disease outcomes among SLE patients of European descent. Moreover, these results suggest that genetic studies of SLE subphenotypes will need to carefully address issues of population substructure based on genetic ancestry.
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