ReviewNeurocritical care2009
Contemporary management of traumatic intracranial hypertension: is there a role for therapeutic hypothermia?
Review in Neurocritical care, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 88 citations in OpenAlex.
- Hypothermia for neuroprotection in adults after cardiopulmonary resuscitation.The Cochrane database of systematic reviews · 2016Pooled it
- Slow rewarming improved the neurological outcomes of prolonged mild therapeutic hypothermia in patients with severe traumatic brain injury and an evacuated hematoma.Scientific reports · 2018Trial
- Is There a Place for Cerebrospinal Fluid External Lumbar Drainage in Posttraumatic Intracranial Hypertension? Pros, Cons, and Uncertainties.Neurocritical care · 2025Article
- The efficacy of therapeutic hypothermia in patients with poor-grade aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis.Acute and critical care · 2024Article
- Neuromonitoring after Pediatric Cardiac Arrest: Cerebral Physiology and Injury Stratification.Neurocritical care · 2024Review
- Multimodal monitoring combined with hypothermia for the management of severe traumatic brain injury: A case report.Experimental and therapeutic medicine · 2018Article
- Hypothermia for Increased Intracranial Pressure: Is It Dead?Current neurology and neuroscience reports · 2016Review
- Impact of Infection on Stroke Morbidity and Outcomes.Current neurology and neuroscience reports · 2016Review
- Neuroprotective effects of bloodletting at Jing points combined with mild induced hypothermia in acute severe traumatic brain injury.Neural regeneration research · 2016Article
- Therapeutic hypothermia and targeted temperature management in traumatic brain injury: Clinical challenges for successful translation.Brain research · 2016Review
- Inferior Vena Cava Thrombosis Related to Hypothermia Catheter: Report of 20 Consecutive Cases.Neurocritical care · 2015Article
- Therapeutic hypothermia for acute brain injuries.Scandinavian journal of trauma, resuscitation and emergency medicine · 2015Review
- Postsurgical meningitis complicated by severe refractory intracranial hypertension with limited treatment options: the role of mild therapeutic hypothermia.Journal of neurological surgery reports · 2014Article
- Capillary transit time heterogeneity and flow-metabolism coupling after traumatic brain injury.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2014Review
- Clinical practice guidelines for the medical and surgical management of primary intracerebral hemorrhage in Korea.Journal of Korean Neurosurgical Society · 2014Review
- Critical care for patients with massive ischemic stroke.Journal of stroke · 2014Review
- Hypothermia protects human neurons.International journal of stroke : official journal of the International Stroke Society · 2014Article
- Revisiting therapeutic hypothermia for severe traumatic brain injury... again.Critical care (London, England) · 2014Article
- The use of targeted temperature management for elevated intracranial pressure.Current neurology and neuroscience reports · 2014Review
- Decompressive craniectomy for management of traumatic brain injury: an update.Current neurology and neuroscience reports · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIntracranial hypertension (ICH) remains the single most difficult therapeutic challenge for the acute management of severe traumatic brain injury (TBI). We reviewed the published trials of therapeutic moderate hypothermia to determine its effect on ICH and compared its efficacy to other commonly used therapies for ICH.
methodsA PubMed database search was done using various combinations of the search terms "brain injury," "therapeutic hypothermia," "intracranial hypertension," "barbiturates," "mannitol," "hypertonic saline," "hyperventilation," "decompressive craniectomy," and "CSF drainage."
resultsWe identified 11 prospective randomized clinical TBI trials comparing hypothermia vs. normothermia treatment for which intracranial pressure (ICP) data was provided, and 6 prospective cohort studies that provided ICP data before and during hypothermia treatment. In addition, we identified 37 clinical TBI studies of lumbar CSF drainage, mannitol, hyperventilation, barbiturates, hypertonic saline, and decompressive craniectomy that provided pre- and posttreatment ICP data. Hypothermia was at least as effective as the traditional therapies for ICH (hyperventilation, mannitol, and barbiturates), but was less effective than hypertonic saline, lumbar CSF drainage, and decompressive craniectomy. Ultimately, however, therapeutic hypothermia does appear to have a favorable risk/benefit profile.
conclusionTherapeutic moderate hypothermia is as effective, or more effective, than most other treatments for ICH. If used for 2-3 days or less there is no evidence that it causes clinically significant adverse events. The lack of consistent evidence that hypothermia improves long-term neurologic outcome should not preclude consideration of its use for the primary treatment of ICH since no other ICP therapy is held to this standard.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.