ArticleInflammation research : official journal of the European Histamine Research Society ... [et al.]2010
Enhanced topical delivery and ex vivo anti-inflammatory activity from a betamethasone dipropionate formulation containing fish oil.
Article in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2010. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 39 citations in OpenAlex.
- Enhanced Anti-Inflammatory and Skin Barrier Repair Effects of Nanoemulsions Supplemented withACS nanoscience Au · 2025Article
- Can Essential Oils/Botanical Agents Smart-Nanoformulations Be the Winning Cards against Psoriasis?Pharmaceutics · 2023Review
- Betamethasone Dipropionate Nanocrystals: Investigation, Feasibility and In Vitro Evaluation.AAPS PharmSciTech · 2022Article
- AnJournal of biological methods · 2020Review
- Prostaglandin EThe Journal of allergy and clinical immunology · 2018Article
- Novel Fish Oil-based Bigel System for Controlled Drug Delivery and its Influence on Immunomodulatory Activity of Imiquimod Against Skin Cancer.Pharmaceutical research · 2017Article
- Enhancement of Anti-Dermatitis Potential of Clobetasol Propionate by DHA [Docosahexaenoic Acid] Rich Algal Oil Nanoemulsion Gel.Iranian journal of pharmaceutical research : IJPR · 2016Article
- Nanocarrier-based hydrogel of betamethasone dipropionate and salicylic acid for treatment of psoriasis.International journal of pharmaceutical investigation · 2011Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
OBJECTIVE AND
designTo probe ex vivo the influence of fish oil (FO) on the topical delivery and anti-inflammatory properties of betamethasone dipropionate (BD). MATERIALS OR SUBJECTS: Freshly excised porcine ear skin. TREATMENT: Ointment formulations containing BD + salicylic acid (SA), BD + SA + FO, or base as control, applied to the skin mounted in Franz cells.
methodsComparative depth profiling; skin probed by immunohistochemistry for cyclooxygenase-2 (COX-2) and by ELISA for prostaglandin E2 (PGE2).
resultsMore BD was obtained in the first 30 layers and the remaining epidermis with BD + SA. However, more penetrants were recovered from the remaining skin treated with BD + SA + FO. Although BD + SA reduced COX-2 expression within the epidermis, greater reduction was observed with BD + SA + FO as indicated by reduced COX-2 expression. FO alone had a comparable effect on the expression of COX-2. Modulation of PGE2 production also supported the anti-inflammatory properties of fish oil, reducing PGE2 levels by an amount comparable to the reduction by BD. Combining FO and BD, however, did not provide the anticipated potentiation effect.
conclusionsFish oil enhanced the delivery of BD and SA across skin. Addition of fish oil also enhanced the anti-inflammatory activity of BD, attributed to increased amounts of BD present in the skin and/or the intrinsic anti-inflammatory activity of fish oil.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.