ArticleParasitology research2009
Mechanism involved in phagocytosis and killing of Listeria monocytogenes by Acanthamoeba polyphaga.
Article in Parasitology research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 30 citations in OpenAlex.
- On the origin of the functional versatility of macrophages.Frontiers in physiology · 2023Article
- War of the microbial world: Acanthamoeba spp. interactions with microorganisms.Folia microbiologica · 2021Review
- Insight into the Lifestyle of AmoebaMicroorganisms · 2020Article
- Experimental Listeria-Tetrahymena-Amoeba food chain functioning depends on bacterial virulence traits.BMC ecology · 2019Article
- A Mutation in theInternational journal of molecular sciences · 2018Article
- The number of genes encoding repeat domain-containing proteins positively correlates with genome size in amoebal giant viruses.Virus evolution · 2018Article
- Free-Living Amoebae as Hosts for and Vectors of Intracellular Microorganisms with Public Health Significance.Viruses · 2017Review
- Relevance of free-living amoebae as hosts for phylogenetically diverse microorganisms.Parasitology research · 2014Review
- Mechanisms associated with phagocytosis of Arcobacter butzleri by Acanthamoeba castellanii.Parasitology research · 2014Article
- Effect of environmental stress factors on the uptake and survival of Campylobacter jejuni in Acanthamoeba castellanii.BMC microbiology · 2012Article
- To forge a solid immune recognition.Protein & cell · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Intra-cellular pathogen, Listeria monocytogenes, is capable of invasion and survival within mammalian cells. However, Acanthamoeba polyphaga trophozoites phagocytose and rapidly degrade Listeria cells. In order to provide more information on amoeba phagocytosis and killing mechanisms, this study used several inhibitor agents known to affect the phagocytosis and killing of bacteria by eukaryotes. Amoebae were pre-treated with mannose, cytochalasin D, wortmannin, suramin, ammonium chloride, bafilomycin A and monensin followed by co-culture with bacteria. Phagocytosis and killing of bacterial cells by amoeba trophozoites was assessed using plate counting methods and microscopy. The data presented indicates that actin polymerisation and cytoskeletal rearrangement are involved in phagocytosis of L. monocytogenes cells by A. polyphaga trophozoites. Further, both phagosomal acidification and phagosome-lysosome fusion are involved in killing and degradation of L. monocytogenes cells by A. polyphaga. However, the mannose-binding protein receptor does not play an important role in uptake of bacteria by amoeba trophozoites. In conclusion, this data reveals the similar principles of molecular mechanisms used by different types of eukaryotes in uptake and killing of bacteria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.