Evidence map›Paper›PMID 19644370›Full record

ReviewCurrent opinion in organ transplantation2009

Deconvoluting the 'omics' for organ transplantation.

Minnie M Sarwal

Abstract readReview
In one paragraph

Review in Current opinion in organ transplantation, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Article
  6. Proteomics and metabolomics in renal transplantation-quo vadis?Transplant international : official journal of the European Society for Organ Transplantation · 2013
    Review
  7. Article
  8. Review
  9. Identifying biomarkers as diagnostic tools in kidney transplantation.Expert review of molecular diagnostics · 2011
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author.

Minnie M SarwalDepartment of Pediatrics, Stanford University, Stanford, California, USA. msarwal@stanford.edu

Funding

Defining Biomarkers in Pediatric Renal TransplantationR01AI061739 · NIAID · STANFORD UNIVERSITY · PI SARWAL, MINNIE M · 2004 to 2007
$1.6M
NIAID NIH HHS R01 AI-061739NIAID NIH HHS R01 AI061739
6 · The paper itself

Abstract

purpose of reviewThe desire for biomarkers for diagnosis and prognosis of diseases has never been greater. With the availability of genome data and an increased availability of proteome data, the discovery of biomarkers has become increasingly feasible. This article reviews some recent applications of the many evolving 'omic technologies to organ transplantation. RECENT

findingsWith the advancement of many high-throughput 'omic techniques such as genomics, metabolomics, antibiomics, peptidomics, and proteomics, efforts have been made to understand potential mechanisms of specific graft injuries and develop novel biomarkers for acute rejection, chronic rejection, and operational tolerance. SUMMARY: The translation of potential biomarkers from the laboratory bench to the clinical bedside is not an easy task and will require the concerted effort of the immunologists, molecular biologists, transplantation specialists, geneticists, and experts in bioinformatics. Rigorous prospective validation studies will be needed using large sets of independent patient samples. The appropriate and timely exploitation of evolving 'omic technologies will lay the cornerstone for a new age of translational research for organ transplant monitoring.

Indexed as

BiomarkersComputational BiologyGenomicsGraft RejectionHumansOrgan TransplantationPeptidesProteomicsBiomarkersPeptides

Identifiers

PMID19644370
PMCPMC2993238

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.