ArticleProceedings of the Japan Academy. Series B, Physical and biological sciences2009
Regulation of succinate-ubiquinone reductase and fumarate reductase activities in human complex II by phosphorylation of its flavoprotein subunit.
Article in Proceedings of the Japan Academy. Series B, Physical and biological sciences, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 53 citations in OpenAlex.
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- In-Depth Computational Analysis of Natural and Artificial Carbon Fixation Pathways.Biodesign research · 2021Article
- Differential posttranslational modification of mitochondrial enzymes corresponds with metabolic suppression during hibernation.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson's disease.Scientific reports · 2019Article
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- Selective Cytotoxicity of Dihydroorotate Dehydrogenase Inhibitors to Human Cancer Cells Under Hypoxia and Nutrient-Deprived Conditions.Frontiers in pharmacology · 2018Article
- Mitochondrial metabolic remodeling in response to genetic and environmental perturbations.Wiley interdisciplinary reviews. Systems biology and medicine · 2016Review
- Structural Insights into the Molecular Design of Flutolanil Derivatives Targeted for Fumarate Respiration of Parasite Mitochondria.International journal of molecular sciences · 2015Article
- Succinate Dehydrogenase Loss in Familial Paraganglioma: Biochemistry, Genetics, and Epigenetics.International journal of endocrinology · 2015Review
- Control mechanisms in mitochondrial oxidative phosphorylation.Neural regeneration research · 2013Article
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- Reprofiling a classical anthelmintic, pyrvinium pamoate, as an anti-cancer drug targeting mitochondrial respiration.Frontiers in oncology · 2012Article
- Mitochondrial respiration and succinate dehydrogenase are suppressed early during entrance into a hibernation bout, but membrane remodeling is only transient.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2011Article
- Mitochondria in heart failure.Cardiovascular research · 2010Review
- Succinate dehydrogenase - Assembly, regulation and role in human disease.Mitochondrion · 2010Review
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Complex II (succinate-ubiquinone reductase; SQR) is a mitochondrial respiratory chain enzyme that is directly involved in the TCA cycle. Complex II exerts a reverse reaction, fumarate reductase (FRD) activity, in various species such as bacteria, parasitic helminths and shellfish, but the existence of FRD activity in humans has not been previously reported. Here, we describe the detection of FRD activity in human cancer cells. The activity level was low, but distinct, and it increased significantly when the cells were cultured under hypoxic and glucose-deprived conditions. Treatment with phosphatase caused the dephosphorylation of flavoprotein subunit (Fp) with a concomitant increase in SQR activity, whereas FRD activity decreased. On the other hand, treatment with protein kinase caused an increase in FRD activity and a decrease in SQR activity. These data suggest that modification of the Fp subunit regulates both the SQR and FRD activities of complex II and that the phosphorylation of Fp might be important for maintaining mitochondrial energy metabolism within the tumor microenvironment.
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