Trial reportAmerican journal of epidemiology2009
The effect of strict adherence to a high-fiber, high-fruit and -vegetable, and low-fat eating pattern on adenoma recurrence.
Trial report in American journal of epidemiology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- Trial
- Effects of a high-fiber, high-fruit and high-vegetable, low-fat dietary intervention on the rectal tissue microbiome.Journal of the National Cancer Institute · 2025Trial
- Colonic Mucosal Bacteria Are Associated with Inter-Individual Variability in Serum Carotenoid Concentrations.Journal of the Academy of Nutrition and Dietetics · 2018Trial
- Effects of a Mediterranean Diet Intervention on Anti- and Pro-Inflammatory Eicosanoids, Epithelial Proliferation, and Nuclear Morphology in Biopsies of Normal Colon Tissue.Nutrition and cancer · 2015Trial
- Development of exchange lists for Mediterranean and Healthy Eating diets: implementation in an intervention trial.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2014Trial
- Relationships between serum and colon concentrations of carotenoids and fatty acids in randomized dietary intervention trial.Cancer prevention research (Philadelphia, Pa.) · 2013Trial
- A review of dietary patterns and the colorectal polyp-to-carcinoma sequence: polyp occurrence, polyp recurrence, and colorectal cancer.Frontiers in nutrition · 2026Review
- Associations Between Prescreening Dietary Patterns and Longitudinal Colonoscopy Outcomes in Veterans.Federal practitioner : for the health care professionals of the VA, DoD, and PHS · 2025Article
- The gut microbiome and dietary fibres: implications in obesity, cardiometabolic diseases and cancer.Nature reviews. Microbiology · 2025Review
- Long-Term Randomized Controlled Trials of Diet Intervention Reports and Their Impact on Cancer: A Systematic Review.Cancers · 2024Review
- Review
- Dietary Factors Modulating Colorectal Carcinogenesis.Nutrients · 2021Review
- Establishment and Verification of Scoring System for Colorectal Adenoma Recurrence.Risk management and healthcare policy · 2021Article
- Whole Fruits and Fruit Fiber Emerging Health Effects.Nutrients · 2018Review
- Translating Mechanism-Based Strategies to Break the Obesity-Cancer Link: A Narrative Review.Journal of the Academy of Nutrition and Dietetics · 2018Review
- Intake of dietary fibre and lifetime non-steroidal anti-inflammatory drug (NSAID) use and the incidence of colorectal polyps in a population screened for colorectal cancer.Journal of epidemiology and community health · 2017Article
- Multiple behavioral factors are associated with occurrence of large, flat colorectal polyps.International journal of colorectal disease · 2017Article
- Article
- Dietary lifestyle and colorectal cancer onset, recurrence, and survival: myth or reality?Journal of gastrointestinal cancer · 2013Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Individual differences in dietary intake are thought to account for substantial variation in cancer incidence. However, there has been a consistent lack of effect for low-fat, high-fiber dietary interventions and risk of colorectal cancer. These inconsistencies may reflect the multistage process of cancer as well as the range and timing of dietary change. Another potential reason for the lack of effect is poor dietary adherence among participants in these trials. The authors examined the effect of strict adherence to a low-fat, high-fiber, high-fruit and -vegetable intervention over 4 years among participants (n = 1,905) in the US Polyp Prevention Trial (1991-1998) on colorectal adenoma recurrence. There was a wide range of individual variation in the level of compliance among intervention participants. The most adherent participants, defined as "super compliers" (n = 210), consistently reported that they met or exceeded each of the 3 dietary goals at all 4 annual visits. Multivariate logistic regression models were used to estimate the association between dietary adherence and adenoma recurrence. The authors observed a 35% reduced odds of adenoma recurrence among super compliers compared with controls (odds ratio = 0.65, 95% confidence interval: 0.47, 0.92). Findings suggest that high compliance with a low-fat, high-fiber diet is associated with reduced risk of adenoma recurrence.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.