ArticleDevelopmental biology2009
Two Hox cofactors, the Meis/Hth homolog UNC-62 and the Pbx/Exd homolog CEH-20, function together during C. elegans postembryonic mesodermal development.
Article in Developmental biology, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- An expandable FLP-ON::TIR1 system for precise spatiotemporal protein degradation in Caenorhabditis elegans.Genetics · 2023Article
- Article
- DamID identifies targets of CEH-60/PBX that are associated with neuron development and muscle structure in Caenorhabditis elegans.PloS one · 2020Article
- CEH-60/PBX regulates vitellogenesis and cuticle permeability through intestinal interaction with UNC-62/MEIS in Caenorhabditis elegans.PLoS biology · 2019Article
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans.Developmental biology · 2014Article
- CEH-20/Pbx and UNC-62/Meis function upstream of rnt-1/Runx to regulate asymmetric divisions of the C. elegans stem-like seam cells.Biology open · 2013Article
- Integrative analysis of C. elegans modENCODE ChIP-seq data sets to infer gene regulatory interactions.Genome research · 2013Article
- A network model for the specification of vulval precursor cells and cell fusion control in Caenorhabditis elegans.Frontiers in genetics · 2013Article
- Roles of the developmental regulator unc-62/Homothorax in limiting longevity in Caenorhabditis elegans.PLoS genetics · 2013Article
- Transcription factor redundancy and tissue-specific regulation: evidence from functional and physical network connectivity.Genome research · 2012Article
- Human developmental enhancers conserved between deuterostomes and protostomes.PLoS genetics · 2012Article
- Spatial regulation of lag-2 transcription during vulval precursor cell fate patterning in Caenorhabditis elegans.Genetics · 2011Article
- The C. elegans SoxC protein SEM-2 opposes differentiation factors to promote a proliferative blast cell fate in the postembryonic mesoderm.Development (Cambridge, England) · 2011Article
- The RGM protein DRAG-1 positively regulates a BMP-like signaling pathway in Caenorhabditis elegans.Development (Cambridge, England) · 2010Article
- The FoxF/FoxC factor LET-381 directly regulates both cell fate specification and cell differentiation in C. elegans mesoderm development.Development (Cambridge, England) · 2010Article
- Somatic muscle specification during embryonic and post-embryonic development in the nematode C. elegans.Wiley interdisciplinary reviews. Developmental biologyReview
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3 authors.
Funding
Abstract
The TALE homeodomain-containing PBC and MEIS proteins play multiple roles during metazoan development. Mutations in these proteins can cause various disorders, including cancer. In this study, we examined the roles of MEIS proteins in mesoderm development in C. elegans using the postembryonic mesodermal M lineage as a model system. We found that the MEIS protein UNC-62 plays essential roles in regulating cell fate specification and differentiation in the M lineage. Furthermore, UNC-62 appears to function together with the PBC protein CEH-20 in regulating these processes. Both unc-62 and ceh-20 have overlapping expression patterns within and outside of the M lineage, and they share physical and regulatory interactions. In particular, we found that ceh-20 is genetically required for the promoter activity of unc-62, providing evidence for another layer of regulatory interactions between MEIS and PBC proteins.
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