ArticleBrain research2009
Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions.
Article in Brain research, 2009. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
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Who cites it
58 citing papers in PubMed.
- A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity.bioRxiv : the preprint server for biology · 2026Article
- The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview.Advances in neurobiology · 2024Review
- Role of mGlu5 in Persistent Forms of Hippocampal Synaptic Plasticity and the Encoding of Spatial Experience.Cells · 2022Review
- Article
- Destruction of ERP responses to deviance in an auditory oddball paradigm in amyloid infusion mice with memory deficits.PloS one · 2020Article
- Abnormal auditory mismatch fields in adults with autism spectrum disorder.Neuroscience letters · 2019Article
- Altered hippocampal gene expression and structure in transgenic mice overexpressing neuregulin 1 (Nrg1) type I.Translational psychiatry · 2018Article
- Overexpression of Neuregulin 1 Type III Confers Hippocampal mRNA Alterations and Schizophrenia-Like Behaviors in Mice.Schizophrenia bulletin · 2018Article
- Toward the Language Oscillogenome.Frontiers in psychology · 2018Article
- Down-Regulation of Neuregulin1/ErbB4 Signaling in the Hippocampus Is Critical for Learning and Memory.Molecular neurobiology · 2017Article
- Behavioral abnormalities with disruption of brain structure in mice overexpressing VGF.Scientific reports · 2017Article
- ErbB4 signaling in the prelimbic cortex regulates fear expression.Translational psychiatry · 2017Article
- Ablation of neuropsin-neuregulin 1 signaling imbalances ErbB4 inhibitory networks and disrupts hippocampal gamma oscillation.Translational psychiatry · 2017Article
- Sociability Deficits and Altered Amygdala Circuits in Mice Lacking Pcdh10, an Autism Associated Gene.Biological psychiatry · 2017Article
- Delayed Mismatch Field Latencies in Autism Spectrum Disorder with Abnormal Auditory Sensitivity: A Magnetoencephalographic Study.Frontiers in human neuroscience · 2017Article
- Altered resonance properties of somatosensory responses in mice deficient for the schizophrenia risk gene Neuregulin 1.Brain structure & function · 2016Article
- The dysconnection hypothesis (2016).Schizophrenia research · 2016Review
- Neuregulin 3 Knockout Mice Exhibit Behaviors Consistent with Psychotic Disorders.Molecular neuropsychiatry · 2016Article
- Sensory encoding in Neuregulin 1 mutants.Brain structure & function · 2016Article
- Oxytocin reduces amygdala activity, increases social interactions, and reduces anxiety-like behavior irrespective of NMDAR antagonism.Behavioral neuroscience · 2015Article
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Authors and funding
11 authors.
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Abstract
introductionNeuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia and plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using mutant mice heterozygous for Nrg1 (Nrg1(+/-)) we studied the effects of Nrg1 signaling on behavioral and electrophysiological measures relevant to schizophrenia. EXPERIMENTAL PROCEDURE: Behavior of Nrg1(+/-) mice and their wild type littermates was evaluated using pre-pulse inhibition, contextual fear conditioning, novel object recognition, locomotor, and social choice paradigms. Event-related potentials (ERPs) were recorded to assess auditory gating and novel stimulus detection.
resultsGating of ERPs was unaffected in Nrg1(+/-) mice, but mismatch negativity in response to novel stimuli was attenuated. The Nrg1(+/-) mice exhibited behavioral deficits in contextual fear conditioning and social interactions, while locomotor activity, pre-pulse inhibition and novel object recognition were not impaired. SUMMARY: Nrg1(+/-) mice had impairments in a subset of behavioral and electrophysiological tasks relevant to the negative/cognitive symptom domains of schizophrenia that are thought to be influenced by glutamatergic and dopaminergic neurotransmission. These mice are a valuable tool for studying endophenotypes of schizophrenia, but highlight that single genes cannot account for the complex pathophysiology of the disorder.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.